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Deric L. Wheeler

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Deric L. Wheeler

ASSISTANT PROFESSOR

Contents

CONTACT INFORMATION

    Phone: (608) 262-7837
    E-mail:

    Mailing Address:
    3159 Wi Institute Medical Research
    1111 Highland Ave
    Madison, WI 53705

Wheeler Lab Page

Wheeler_Lab


Education


Research

  • Mechanisms of acquired resistance to cetuximab
  • Therapeutic approaches to overcome acquired resistance to EGFR based antibody therapies
  • Understanding the role of nuclear receptor tyrosine kinases in cancer


Awards

  • Molecular Targets of Cancer; Keystone Symposia, NCI Scholar 2007
  • Multidisciplinary Head and Neck Cancer Symposium Travel Scholarship Winner, 2007
  • American Cancer Society Postdoctoral Fellowship, 2006-2009 (Grant #: PF-07-089-01-TBE)
  • Fred Hutchinson Cancer Research Center Postdoctoral Fellow Travel Scholarship, 2006
  • American Cancer Society Postdoctoral Fellowship, 2006-2006 (Grant #: PF-06-025-01-DDC)
  • AACR Scholar-in-Training Award, AACR Annual Meeting, 2004
  • The Vilas Fellowship, International Travel Award, 2002
  • Phi Sigma National Biological Society
  • Dean's list University of Idaho 1994-1996


Recent Publications

Hanneke Stegeman, Johannes H Kaanders, Deric L Wheeler, Albert J van der Kogel, Marieke M Verheijen, Stijn J Waaijer, Mari Iida, Reidar Grénman, Paul N Span, Johan Bussink
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.
BMC Cancer: 2012, 12(1);463
[PubMed:23046567]

Toni M Brand, Mari Iida, Emily F Dunn, Neha Luthar, Kellie T Kostopoulos, Kelsey L Corrigan, Matthew J Wleklinski, David Yang, Kari B Wisinski, Ravi Salgia, Deric L Wheeler
Nuclear Epidermal Growth Factor Receptor is a Functional Molecular Target in Triple-Negative Breast Cancer.
Mol. Cancer Ther.: 2014;
[PubMed:24634415]

Mari Iida, Toni M Brand, Megan M Starr, Chunrong Li, Evan J Huppert, Neha Luthar, Mikkel W Pedersen, Ivan D Horak, Michael Kragh, Deric L Wheeler
Sym004, a Novel EGFR Antibody Mixture, Can Overcome Acquired Resistance to Cetuximab.
Neoplasia: 2013, 15(10);1196-206
[PubMed:24204198]

Chunrong Li, Toni M Brand, Mari Iida, Shyhmin Huang, Eric A Armstrong, Albert van der Kogel, Deric L Wheeler
Human epidermal growth factor receptor 3 (HER3) blockade with U3-1287/AMG888 enhances the efficacy of radiation therapy in lung and head and neck carcinoma.
Discov Med: 2013, 16(87);79-92
[PubMed:23998444]

Toni M Brand, Mari Iida, Neha Luthar, Matthew J Wleklinski, Megan M Starr, Deric L Wheeler
Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3.
PLoS ONE: 2013, 8(8);e71518
[PubMed:23951180]

Toni M Brand, Mari Iida, Neha Luthar, Megan M Starr, Evan J Huppert, Deric L Wheeler
Nuclear EGFR as a molecular target in cancer.
Radiother Oncol: 2013;
[PubMed:23830194]

Deric L Wheeler, Ajit K Verma, Mitchell F Denning
Mouse models of the skin: models to define mechanisms of skin carcinogenesis.
J Skin Cancer: 2013, 2013();971495
[PubMed:23819053]

Mari Iida, Toni M Brand, David A Campbell, Megan M Starr, Neha Luthar, Anne M Traynor, Deric L Wheeler
Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab.
Cancer Biol. Ther.: 2013, 14(6);481-91
[PubMed:23760490]

Anne M Traynor, Tracey L Weigel, Kurt R Oettel, David T Yang, Chong Zhang, Kyungmann Kim, Ravi Salgia, Mari Iida, Toni M Brand, Tien Hoang, Toby C Campbell, Hilary R Hernan, Deric L Wheeler
Nuclear EGFR protein expression predicts poor survival in early stage non-small cell lung cancer.
Lung Cancer: 2013;
[PubMed:23628526]

Paul A Clark, Mari Iida, Daniel M Treisman, Haviryaji Kalluri, Sathyapriya Ezhilan, Michael Zorniak, Deric L Wheeler, John S Kuo
Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition.
Neoplasia: 2012, 14(5);420-8
[PubMed:22745588]

Toni M Brand, Deric L Wheeler
KRAS mutant colorectal tumors: Past and present.
Small Gtpases: 2012, 3(1);34-9
[PubMed:22714415]

M Iida, T M Brand, D A Campbell, C Li, D L Wheeler
Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor.
Oncogene: 2012;
[PubMed:22430206]

Toni M Brand, Mari Iida, Chunrong Li, Deric L Wheeler
The nuclear epidermal growth factor receptor signaling network and its role in cancer.
Discov Med: 2011, 12(66);419-32
[PubMed:22127113]

Shyhmin Huang, Sergio Benavente, Eric A Armstrong, Chunrong Li, Deric L Wheeler, Paul M Harari
p53 Modulates Acquired Resistance to EGFR Inhibitors and Radiation.
Cancer Res: 2011;
[PubMed:22068033]

Toni M Brand, Emily F Dunn, Mari Iida, Rebecca A Myers, Kellie T Kostopoulos, Chunrong Li, Chimera R Peet, Deric L Wheeler
Erlotinib is a viable treatment for tumors with acquired resistance to cetuximab.
Cancer Biol Ther: 2011, 12(5);
[PubMed:21725209]

Toni M Brand, Mari Iida, Deric L Wheeler
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.
Cancer Biol. Ther.: 2011, 11(9);777-92
[PubMed:21293176]

Toni M Brand, Deric L Wheeler
Treating PIK3CA and EGFR overexpressing breast cancers with lithium citrate.
Cancer Biol. Ther.: 2011, 11(3);368-70
[PubMed:21228636]

Tim J Kruser, Anne M Traynor, Deric L Wheeler
The use of single-agent dasatinib in molecularly unselected non-small-cell lung cancer patients.
Expert Opin Investig Drugs: 2011, 20(2);305-7
[PubMed:21204748]

E F Dunn, M Iida, R A Myers, D A Campbell, K A Hintz, E A Armstrong, C Li, D L Wheeler
Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab.
Oncogene: 2011, 30(5);561-74
[PubMed:20956938]

Chunrong Li, Mari Iida, Emily F Dunn, Deric L Wheeler
Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma.
Radiother Oncol: 2010, 97(2);330-7
[PubMed:20667610]

Deric L Wheeler, Emily F Dunn, Paul M Harari
Understanding resistance to EGFR inhibitors-impact on future treatment strategies.
Nat Rev Clin Oncol: 2010, 7(9);493-507
[PubMed:20551942]

Tim J Kruser, Deric L Wheeler, Eric A Armstrong, Mari Iida, Kevin R Kozak, Albert J van der Kogel, Johan Bussink, Angela Coxon, Anthony Polverino, Paul M Harari
Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors.
Clin. Cancer Res.: 2010, 16(14);3639-47
[PubMed:20507929]

Tim J Kruser, Deric L Wheeler
Mechanisms of resistance to HER family targeting antibodies.
Exp. Cell Res.: 2010, 316(7);1083-100
[PubMed:20064507]

C Li, M Iida, E F Dunn, A J Ghia, D L Wheeler
Nuclear EGFR contributes to acquired resistance to cetuximab.
Oncogene: 2009, 28(43);3801-13
[PubMed:19684613]

Deric L Wheeler, Emily F Dunn
BB, a novel epidermal growth factor receptor inhibitor.
Cancer Biol. Ther.: 2009, 8(17);1648-50
[PubMed:19625764]

Deric L Wheeler, Mari Iida, Emily F Dunn
The role of Src in solid tumors.
Oncologist: 2009, 14(7);667-78
[PubMed:19581523]

Deric L Wheeler, Mari Iida, Tim J Kruser, Meghan M Nechrebecki, Emily F Dunn, Eric A Armstrong, Shyhmin Huang, Paul M Harari
Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab.
Cancer Biol. Ther.: 2009, 8(8);696-703
[PubMed:19276677]

Sergio Benavente, Shyhmin Huang, Eric A Armstrong, Alexander Chi, Kun-Tai Hsu, Deric L Wheeler, Paul M Harari
Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells.
Clin. Cancer Res.: 2009, 15(5);1585-92
[PubMed:19190133]

Paul M Harari, Deric L Wheeler, Jennifer R Grandis
Molecular target approaches in head and neck cancer: epidermal growth factor receptor and beyond.
Semin Radiat Oncol: 2009, 19(1);63-8
[PubMed:19028347]

Tim J Kruser, Eric A Armstrong, Amol J Ghia, Shyhmin Huang, Deric L Wheeler, Robert Radinsky, Daniel J Freeman, Paul M Harari
Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer.
Int. J. Radiat. Oncol. Biol. Phys.: 2008, 72(2);534-42
[PubMed:18793955]

D L Wheeler, Vivek M Rangnekar, S R Schwarze
ErbB4 targeting approaches for prostate cancer treatment.
Cancer Biol. Ther.: 2008, 7(7);1095-7
[PubMed:18698169]

D L Wheeler, S Huang, T J Kruser, M M Nechrebecki, E A Armstrong, S Benavente, V Gondi, K-T Hsu, P M Harari
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members.
Oncogene: 2008, 27(28);3944-56
[PubMed:18297114]

Ajit K Verma, Deric L Wheeler, Moammir H Aziz, Herbert Manoharan
Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer.
Mol. Carcinog.: 2006, 45(6);381-8
[PubMed:16683253]

Moammir H Aziz, Deric L Wheeler, Bhushan Bhamb, Ajit K Verma
Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2.
Cancer Res.: 2006, 66(2);713-22
[PubMed:16424000]

Yafan Li, Deric L Wheeler, Wade Alters, Luksana Chaiswing, Ajit K Verma, Terry D Oberley
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.
Toxicol Pathol: 2005, 33(6);684-94
[PubMed:16243773]

Deric L Wheeler, Peter J Reddig, Kristin J Ness, Catherine P Leith, Terry D Oberley, Ajit K Verma
Overexpression of protein kinase C-{epsilon} in the mouse epidermis leads to a spontaneous myeloproliferative-like disease.
Am. J. Pathol.: 2005, 166(1);117-26
[PubMed:15632005]

Deric L Wheeler, Kaitlin E Martin, Kristin J Ness, Yafan Li, Nancy E Dreckschmidt, Marybeth Wartman, Honnavara N Ananthaswamy, David L Mitchell, Ajit K Verma
Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas.
Cancer Res.: 2004, 64(21);7756-65
[PubMed:15520180]

D L Wheeler, Y Li, Ajit K Verma
Protein kinase C epsilon signals ultraviolet light-induced cutaneous damage and development of squamous cell carcinoma possibly through Induction of specific cytokines in a paracrine mechanism.
Photochem. Photobiol.: , 81(1);9-18
[PubMed:15458367]

Deric L Wheeler, Kristin J Ness, Terry D Oberley, Ajit K Verma
Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.
Cancer Res.: 2003, 63(19);6547-55
[PubMed:14559850]

Deric L Wheeler, Kristin J Ness, Terry D Oberley, Ajit K Verma
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Cancer Res.: 2003, 63(12);3037-42
[PubMed:12810623]

Deric L Wheeler, Peter J Reddig, Nancy E Dreckschmidt, Michael Leitges, Ajit K Verma
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
Oncogene: 2002, 21(22);3620-30
[PubMed:12032864]

A P Jansen, N E Dreckschmidt, E G Verwiebe, D L Wheeler, T D Oberley, A K Verma
Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice.
Int. J. Cancer: 2001, 93(5);635-43
[PubMed:11477572]

A P Jansen, E G Verwiebe, N E Dreckschmidt, D L Wheeler, T D Oberley, A K Verma
Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma.
Cancer Res.: 2001, 61(3);808-12
[PubMed:11221859]