Harari Lab Members Publications Posters Directions Protocols Links
Deric L. Wheeler
American Cancer Society Postdoctoral Fellow
600 Highland Avenue
K4/319 CSC
Madison, WI 53792
Telephone: 608-265-3716
Fax: 263-9947
E-mail:
- University of Wisconsin-Madison, School of Medicine and Public Health, ACS Postdoctoral Fellow
- Fred Hutchinson Cancer Research Center, Seattle, WA, ACS Postdoctoral Fellow
- University of Wisconsin-Madison, School of Medicine and Public Health, Human Cancer Biology PhD
- University of Iowa, College of Medicine, Iowa City, IA, Pathology MS
- University of Idaho, Moscow, ID, Botany and Zoology BS
- Mechanisms of acquired resistance to cetuximab
- Therapeutic approaches to overcome acquired resistance to EGFR inhibitors
1. DL Wheeler and AK Verma, PKCepsilon is essential for the development of metastatic squamous cell carcinoma in the mouse skin (in preparation) (2006)
2. AK Verma, DL Wheeler, MH Aziz and H Manoharan, Review; Protein Kinase C epsilon is the key mediator of Skin Carcinogenesis, Molecular Carcinogenesis 45:381–388 (2006)
3. Y Li, DL Wheeler, W Shan, J Bourdeau-Heller, HN Ananthaswamy, AK Verma, and TD Oberley, Mechanistic Insights into the Development of the Papilloma-independent Metastatic Squamous Cell Carcinoma Phenotype in PKCepsilon Overexpression Transgenic Mice in a Skin Chemical Carcinogenesis Model (Submitted) Cancer Research (2006)
4. MH. Aziz, DL Wheeler, B Bhamb and AK. Verma, Protein kinase c delta is not a tumor suppressor in ultraviolet radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2, Cancer Research, 66:(2), 713, (2006)
5. Y Li, DL Wheeler, W Alters, L Chaiswing, AK Verma, and TD Oberley, Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKC epsilon overexpressing transgenic mice. Toxicol Pathol, 33: 684-694, (2005)
6. DL Wheeler and Y Li, AK Verma, Development of metastatic squamous cell carcinomas in PKC epsilon transgenic mice is possibly mediated by proinflammatory cytokines in a paracrine mechanism. Journal of Photochemistry and Photobiology, 81:9-18 (2005).
7. DL Wheeler, KJ Ness, TD Oberley, and AK Verma, Overexpression of Protein Kinase C epsilon in the mouse epidermis leads to a spontaneous non-neoplastic myeloproliferative disease. American Journal of Pathology, 166:1 117-126 (2005).
8. DL Wheeler, KE Martin, KJ Ness, Y Li, NE Dreckschmidt, M Wartman, HN Ananthaswamy, DL Mitchell, AK Verma, Protein Kinase epsilon Is an Endogenous Photosensitizer That Enhances Ultraviolet Radiation-Induced Cutaneous Damage and Development of Squamous Cell Carcinomas. Cancer Research, 64: 7756, (2004)
9. DL Wheeler, KJ Ness, TD Oberley, and AK Verma, Protein Kinase C epsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor alpha ectodomain shedding and to the development of metastatic squamous cell carcinoma in Protein Kinase C epsilon transgenic mice. Cancer Research, 63: 6547, (2003).
10. DL Wheeler, KJ Ness, TD Oberley, and AK Verma, Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-Difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. Cancer Research, Advances in Brief; 63:3037 (2003).
11. DL Wheeler, PJ Reddig, NE Dreckschmidt, and AK Verma, Protein Kinase C Delta-mediated signals to ornithine decarboxylase induction and to suppression of skin tumor promotion are independent. Oncogene, 21:3620 (2002).
12. AP Jansen, NE Dreckschmidt, EG Verwiebe, DL Wheeler, TD Oberley, and AK Verma, Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, delta and epsilon transgenic mice. International Journal of Cancer: 93, 635 (2001).
13. AP Jansen, EG Verwiebe, NE Dreckschmidt, DL Wheeler, TD Oberley, and AK Verma, Protein kinase C-epsilon transgenic mice: a unique model for metastatic squamous cell carcinoma. Cancer Research: 61, 808 (2001).
Posters
1. S Huang, DL Wheeler, M Cannon, and PM Harari, Alterations in EGFR trafficking and degradation in EGFR-inhibitor resistant tumor cells, Proc. Am. Assoc. Cancer Res., 48:1258, Los Angeles, CA 2007. (pdf)
2. DL Wheeler, TJ Kruser, MM Nechrebecki, S Huang, PM Harari, Acquired Resistance to Cetuximab; Rationale for Sequential Therapies Targeting the EGFR, Molecular Targets of Cancer; Keystone Symposia, Whistler, British Columbia, 2007(pdf)
3. TJ Kruser, DL Wheeler, S Huang, EA Armstrong, M Sliwkowski, D Hicklin and PM Harari, Dual Agent Targeting of EGFR and ErbB2 with Cetuximab and 2C4: A Strategy to Overcome Acquired Resistance, 2007 Multidisciplinary Head and Neck Cancer Symposium, Palm Springs, 2007 (pdf)
4. DL Wheeler, TJ Kruser, S Huang, V Gondi, EA Armstrong and PM Harari Development and characterization of EGFR inhibitor resistant lines; A model to study acquired resistance to EGFR blockade, Molecular Diagnostics in Cancer Therapeutic Development, Chicago, IL 2006(pdf)
5. MH Aziz, DL Wheeler, B Bhamb, AK Verma, PKC epsilon but not PKC delta overexpression, alters susceptibility to ultra-violet induced development of squamous cell carcinomas, AM. Assoc. Cancer Res. Washington DC, 2006(pdf)
6. DL Wheeler, TA Anderson, LR Rohrschneider, The sSHIP promoter is expressed during differentiation and proliferation phases of the mouse epidermis, Timberline Symposium on Epithelial Cell Biology, Timberline, OR 2006
7. DL Wheeler, TA Anderson, LR Rohrschneider, The sSHIP promoter is expressed in the bulge region during anagen of the hair follicle cycle. Fred Hutchinson Cancer Research Center, Basic Science Division, Annual Retreat, Semiahmoo, WA 2005
8. Y Li, DL Wheeler, W Alter, L Chaiswing, HN Ananthaswamy, AK Verma, TD Oberley, Analysis of Early Morphologic Changes and Cytokine Levels in Mouse Skin Following a Single 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate Treatment: the Effect of Constitutive overexpression of PKC epsilon;Am. Assoc. Cancer Res. Anaheim, CA, 2005
9. AK Verma, DL Wheeler, KJ Ness, KE Martin, Protein kinase C epsilon is not a tumor suppressor in ultraviolet light-induced mouse skin carcinogenesis. Am. Assoc. Cancer Res. Anaheim, CA, 2005
10. DL Wheeler and AK Verma, Tumor necrosis factor alpha, a proinflammatory cytokine, is linked to the susceptibility of protein kinase C transgenic mice to ultraviolet radiation--induced cutaneous damage and development of squamous cell carcinoma. American Society for Photobiology, Seattle WA, July 2004.
11. DL Wheeler, KJ Ness, KE Martin, NE Dreckschmidt, HN Ananthaswamy, DL Mitchell and AK Verma, Protein Kinase C Epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas. 14th International Congress on Photobiology Jeju, Korea, June, 2004.
12. DL Wheeler and AK Verma, Development of metastatic squamous cell carcinomas in PKC epsilon transgenic mice is possibly mediated by proinflammatory cytokines in a paracrine mechanism. Proc. Am. Assoc. Cancer Res. Orlando, FL, 2004, Awarded AACR Scholar-in-Training Award.
13. AK Verma, HN Ananthaswamy, Y Matsumura and DL Wheeler, Protein Kinase C epsilon is an endogenous photosensitizer in FVB/N mice that enhances UVB radiation-induced tumor necrosis factor alpha release, p53 expression, ornithine decarboxylase activity, the events preceding photocarcinogenesis, American Society of Photobiology, Baltimore, MD, 2003
14. DL Wheeler, KJ Ness, NE Dreckschmidt, TD Oberley and AK Verma, Protein Kinase C epsilon transgenic mice: A unique model to investigate myeloproliferative diseases. Proc. Am. Assoc. Cancer Res. Washington, DC, 2003, Late-Breaking Abstract
15. DL Wheeler, KJ Ness, NE Dreckschmidt, TD Oberley and AK Verma, TPA-stimulated serum Tumor Necrosis Factor alpha levels in PKC epsilontransgenic mice: Possible link with PKC epsilon-mediated increased Tumor Necrosis Factor Converting Enzyme (TACE) activity and development of metastatic squamous cell carcinoma. Proc. Am. Assoc. Cancer Res. 44: 3015, Washington, DC 2003
16. Y Li, DL Wheeler, AK Verma and TD Oberley, Inflammation plays and important role in distinguishing the distinct mechanisms of Protein Kinase delta and Protein Kinase epsilon mediate response to 12-0-tetradecanoylphorbol-13-acetate. Society for Investigative Dermatology, 65th Annual Meeting, Miami Beach, FL, 2003
17. DL Wheeler, KJ Ness, NE Dreckschmidt, TD Oberley and AK Verma, Protein Kinase C epsilon transgenic mice: A unique model to investigate myeloproliferative like syndromes, a group of pre-hematopoietic neoplasms. AACR Mouse Models of Cancer Orlando, FL, 2003
18. DL Wheeler, KJ Ness, NE Dreckschmidt, TD Oberley and AK Verma, The role of proinflammatory cytokine TNF alpha in PKC epsilon signaling network in the development of metastatic squamous cell carcinomas. 5th International Skin Carcinogenesis Meeting, Gifu, Japan, October, 2002
19. DL Wheeler, PJ Reddig, NE Dreckschmidt, M Leitges and AK Verma, Protein kinase C-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression. Proc. Am. Assoc. Cancer Res. 43: 5013, San Francisco, CA, 2002
20. DL Wheeler, NE Dreckschmidt, KL Hayes, TD Oberley, H.N. Ananthaswamy, and A.K. Verma, Inhibition of metastatic squamous cell carcinoma development by a-Difluoromethylornithine accompanied by a marked regression of hair follicle growth and alopecia in protein kinase C epsilon transgenic mice. Proc. Am. Assoc. Cancer Res. 43: 5014, San Francisco, CA, 2002
21. DL Wheeler and AK Verma, intron/exon structure and genetic polymorphism of the murine protein kinase Delta gene. Proc. Am. Assoc. Cancer Res. 42: 4012, 2001
22. AP Jansen, EG Verwiebe, NE Dreckschmidt, DL Wheeler, TD Oberley, and AK Verma, Protein kinase C epsilon transgenic mice: A unique model for metastatic squamous cell carcinoma. Proc. Am. Assoc. Cancer Res. 42: 4919, New Orleans, LA, 2001
23. TP Cripe, AD Holub, A Saini, J DeGregori, JM Bergelson, DL Wheeler, EJ Dunphy, Lack of the adenovirus major attachment receptor limits oncolysis of human rhabdomyosarcoma cells by adenovirus. Proc. Am. Assoc. Cancer Res. 41: 2879, San Francisco, CA, 2000
- Molecular Targets of Cancer; Keystone Symposia, NCI Scholar 2007
- Multidisciplinary Head and Neck Cancer Symposium Travel Scholarship Winner, 2007
- American Cancer Society Postdoctoral Fellowship, 2006-2009 (Grant #: PF-07-089-01-TBE)
- Fred Hutchinson Cancer Research Center Postdoctoral Fellow Travel Scholarship, 2006
- American Cancer Society Postdoctoral Fellowship, 2006-2006 (Grant #: PF-06-025-01-DDC)
- AACR Scholar-in-Training Award, AACR Annual Meeting, 2004
- The Vilas Fellowship, International Travel Award, 2002
- Phi Sigma National Biological Society
- Dean's list University of Idaho 1994-1996
