Harari Lab Members Publications Posters Directions Protocols Links
Tim Kruser
600 Highland Avenue
K4/323
Madison, WI 53792
Telephone: 608-265-3716
Fax: 263-9947
E-mail:
- University of Wisconsin-Madison, Molecular Biology, B.S.
- University of Wisconsin School of Medicine and Public Health, M.D
- NIH T32 Postdoctoral Fellowship; Laboratory of Dr. Paul Harari
- Mechanisms of acquired resistance to EGFR monoclonal antibodies
- Therapeutic approaches to overcome acquired resistance to EGFR inhibitors
- EGFR targeted agents in combination with radiation
- Modulation of radiation response with inhibitors of angiogenesis
- Kruser TJ, Bradley KA, Bentzen SM, Anderson BM, Gondi V, Khuntia D, Perlman SB, Tome WA, Chappell RJ, Walker WL, Mehta MP. The Impact of Hybrid PET-CT Scan on Overall Oncologic Management, with a Focus on Radiotherapy Planning: A Prospective, Blinded Study. Technol Cancer Res Treat. 2009 Apr;8(2):149-58. (Pubmed)
- Wheeler DL, Iida M, Kruser TJ, Nechrebecki MM, Dunn EF, Armstrong EA, Huang S, Harari PM. Epidermal growth factor receptor cooperates with Src family kinases in acquired resistance to cetuximab. Cancer Biol Ther. 2009 Apr 22;8(8). (PubMed)
- Kruser TJ, Armstrong EA, Ghia AJ, Huang S, Wheeler DL, Radinsky R, Freeman DJ, Harari PM. Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer. Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):534-42. (PubMed)
- Kruser TJ, Chao ST, Elson P, Barnet GH, Vogelbaum MA, Angelov L, Weil RJ, Pelley R, Suh JH. Multidisciplinary Management of Colorectal Brain Metastases: A Retrospective Study. Cancer. 2008 Jul 1;113(1):158-65. (PubMed)
- Wheeler DL, Huang S, Kruser TJ, Nechrebecki MM, Armstrong EA, Benavente S, Gondi V, Hsu KT, Harari PM. Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members. Oncogene. 2008 Jun 26;27(28):3944-56. (PubMed)
- Kruser TJ, Frank JL, Maginot KR. Recurrent Syncope Secondary to Asystole in an Infant with Wolff-Parkinson-White Syndrome. Clin Pediatr (Phila) 2008 47: 701-704. (PubMed)
- Kruser TJ, Osaki S, Kohmoto T, Chopra PS. Computed Tomography Finding Mimicking Aortic Dissection after a Cabrol Procedure. Asian Cardiovascular & Thoracic Annals, in press.
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Abstracts/Posters
- Kruser TJ, Tome WA, Seo S, Chappell RJ, Scrimger R, Mehta MP. Prognostic factors for complete obliteration of arteriovenous malformations treated with LINAC-based stereotactic radiosurgery. ASTRO Annual Meeting, 2008 (pdf)
- Kruser TJ, Wheeler DL, Huang S, Armstrong EA, Coxon A, Starnes C, Polverino T, Radinsky R, and Harari PM. Modulation of radiation response by motesanib diphosphate in models of head and neck squamous cell carcinoma. AACR Annual Meeting, April 2008 (pdf)
- Wheeler DL, Ghia AJ, Kruser TJ, Nechrebecki MM, Armstrong EA, Huang SM, and Harari PM. Src Family Kinase and the EGFR Cooperate in Acquired Resitance to Cetuximab. AACR Annual Meeting, April 2008 (abstract)
- Wheeler DL, Ghia AJ, Kruser TJ, Armstrong EA, Nechrebecki M, Huang S, and Harari PM. The Role of Src Family Kinases in Acquired Resistance to Cetuximab. AACR Molecular Targets and Cancer Therapeutics, San Francisco, Oct. 2007 (pdf)
- Kruser TJ, Armstrong E, Huang S, Radinsky R, Starnes C, Freeman D, Harari PM. Panitumumab, a fully human anti-EGFR monoclonal antibody, augments radiation response in xenograft models of upper aerodigestive tract cancers. ASTRO Annual Meeting, Oct. 2007 (pdf)
- Kruser TJ, Chao ST, Elson P, Barnett GH, Vogelbaum M, Toms S, Angelov L, Suh JH. Multidisciplinary Management of Colorectal Brain Metastases: a Retrospective Study. ASTRO Annual Meeting, Oct. 2007 (pdf)
- Bradley KA, Kruser TJ, Bentzen SM, Anderson BM, Gondi V, Khuntia D, Perlmann S, Mehta MP. A Prospective Study Comparing CT-based to PET/CT-based Radiation Treatment Planning. ASTRO Annual Meeting, Oct. 2007 (abstract)
- Kruser T, Khuntia D, Jeraj R, Traynor A, Bentzen S, Gentry L, Rowley H, Cezar G, Hartig G, and Harari P. Functional Imaging and Biomarker Assessment in a Phase I Trial Investigating Bevacizumab with Chemoradiation for Locoregionally Advanced Head and Neck Cancer. ASTRO Translational Research in Radiation Oncology Symposium, Sept. 2007 (pdf)
- Kruser TJ, Frank JL, and Maginot KR. Recurrent Syncope Secondary to Asystole in a Pediatric Patient with Wolff-Parkinson-White Syndrome. Heart Rhythm Society Scientific Sessions, May 2007 (pdf)
- S Huang, DL Wheeler, TJ Kruser, PM Harari. Alterations in EGFR trafficking and degradation in EGFR-inhibitor resistant tumor cells. Proc. Am. Assoc. Cancer Res., 48:1258, Los Angeles, April 2007 (pdf)
- DL Wheeler, TJ Kruser, MM Nechrebecki, S Huang, PM Harari. Acquired Resistance to Cetuximab; Rationale for Sequential Therapies Targeting the EGFR. Molecular Targets of Cancer; Keystone Symposia, Whistler, British Columbia, March 2007(pdf)
- TJ Kruser, DL Wheeler, S Huang, EA Armstrong, M Sliwkowski, D Hicklin, PM Harari. Dual Agent Targeting of EGFR and ErbB2 with Cetuximab and 2C4: A Strategy to Overcome Acquired Resistance. Multidisciplinary Head and Neck Cancer Symposium, Jan. 2007 (pdf)
- DL Wheeler, TJ Kruser, S Huang, E. Armstrong, PM Harari. Acquired Resistance to Cetuximab; Rationale for Sequential Therapies Targeting the EGFR. Multidisciplinary Head and Neck Cancer Symposium, Jan. 2007.—Oral Presentation (abstract) (slides)
- Khuntia D, Jeraj R, Kruser T, Traynor A, Bentzen S, Gentry L, Rowley H, Cezar G, Hartig G, Wiederholt P, Harari P. Phase I Trial of Neoadjuvant Bevacizumab Followed by Concurrent Radiation, Cisplatin, and Bevacizumab for Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck. Multidisciplinary Head and Neck Cancer Symposium, Jan. 2007 (pdf)
- DL Wheeler, TJ Kruser, S Huang, V Gondi, EA Armstrong, PM Harari. Development and characterization of EGFR inhibitor resistant lines; A model to study acquired resistance to EGFR blockade. Molecular Diagnostics in Cancer Therapeutic Development, Sept. 2006 (pdf)
- Williams E, Kruser TJ, Gulliver G, Nee L, Chang SM. Prevalence of Coronary Artery Disease in Chronic Kidney Disease As Diagnosed by Abnormal Myocardial Perfusion Imaging. American College of Cardiology Annual Scientific Session, March 2006 (pdf)
- Kruser TJ. Right-Sided Heart Failure in the Setting of Chronic Diarrhea. Proceedings from the 2005 Annual Meeting of the American College of Physicians, Wisconsin Chapter, Sept. 2005 (abstract)