From Human Oncology
Molecular Modulation of Radiation Response
Radiation is a central cancer treatment modality often limited by normal tissue tolerance. The Harari lab investigates how molecular signaling pathways can modulate tumor response to radiation. We explore new approaches to improve radiotherapy outcomes by enhancing tumor cell radiosensitivity and by decreasing radiation toxicity to normal tissues. We focus on a series of promising molecular agents that target various cellular signaling pathways including growth factor receptor signaling and others as shown in the adjacent figure. Close coupling of the laboratory work to the clinical arena has enabled successful translation of promising laboratory findings into single institution and multi-institutional clinical trials.