Colin Harari, MD

Radiation Oncology Resident

Department of Human Oncology


MD, University of Wisconsin-Madison, (2020)

BS, Tufts University, Astrophysics (2010)

  • Quantitative 4D-Digital Subtraction Angiography to Assess Changes in Hepatic Arterial Flow during Transarterial Embolization: A Feasibility Study in a Swine Model Journal of vascular and interventional radiology : JVIR
    Meram E, Harari C, Shaughnessy G, Wagner M, Brace CL, Mistretta CA, Speidel MA, Laeseke PF
    2019 Aug;30(8):1286-1292. doi: 10.1016/j.jvir.2019.01.018. Epub 2019 Jun 1.
    • More

      PURPOSE: To determine the feasibility of using time-resolved 3D-digital subtraction angiography (4D-DSA) for quantifying changes in hepatic arterial blood flow and velocity during transarterial embolization.

      MATERIALS AND METHODS: Hepatic arteriography and selective transarterial embolization were performed in 4 female domestic swine (mean weight, 54 kg) using 100-300-μm microspheres. Conventional 2D and 4D-DSA were performed before, during, and after each embolization. From the 4D-DSA reconstructions, blood flow and velocity values were calculated for hepatic arterial branches using a pulsatility-based algorithm. 4D-DSA velocity values were compared to those measured using an intravascular Doppler wire with a linear regression analysis. Paired t-tests were used to compare data before and after embolization.

      RESULTS: There was a weak-to-moderate but statistically significant correlation of flow velocities measured with 4D-DSA and the Doppler wire (r = 0.35, n = 39, P = .012). For vessels with high pulsatility, the correlation was higher (r = 0.64, n = 11, P = .034), and the relationship between 4D-DSA and the Doppler wire fit a linear model with a positive bias toward the Doppler wire (failed to reject at 95% confidence level, P = .208). 4D-DSA performed after partial embolization showed a reduction in velocity in the embolized hepatic arteries compared to pre-embolization (mean, 3.96 ± 0.74 vs 11.8 2± 2.15 cm/s, P = .006).

      CONCLUSION: Quantitative 4D-DSA can depict changes in hepatic arterial blood velocity during transarterial embolization in a swine model. Further work is needed to optimize 4D-DSA acquisitions and to investigate its applicability in humans.

      PMID:31160194 | DOI:10.1016/j.jvir.2019.01.018

      View details for PubMedID 31160194
  • Microwave Ablation: Comparison of Simultaneous and Sequential Activation of Multiple Antennas in Liver Model Systems Radiology
    Harari CM, Magagna M, Bedoya M, Lee FT, Lubner MG, Hinshaw JL, Ziemlewicz T, Brace CL
    2016 Jan;278(1):95-103. doi: 10.1148/radiol.2015142151. Epub 2015 Jul 2.
    • More

      PURPOSE: To compare microwave ablation zones created by using sequential or simultaneous power delivery in ex vivo and in vivo liver tissue.

      MATERIALS AND METHODS: All procedures were approved by the institutional animal care and use committee. Microwave ablations were performed in both ex vivo and in vivo liver models with a 2.45-GHz system capable of powering up to three antennas simultaneously. Two- and three-antenna arrays were evaluated in each model. Sequential and simultaneous ablations were created by delivering power (50 W ex vivo, 65 W in vivo) for 5 minutes per antenna (10 and 15 minutes total ablation time for sequential ablations, 5 minutes for simultaneous ablations). Thirty-two ablations were performed in ex vivo bovine livers (eight per group) and 28 in the livers of eight swine in vivo (seven per group). Ablation zone size and circularity metrics were determined from ablations excised postmortem. Mixed effects modeling was used to evaluate the influence of power delivery, number of antennas, and tissue type.

      RESULTS: On average, ablations created by using the simultaneous power delivery technique were larger than those with the sequential technique (P < .05). Simultaneous ablations were also more circular than sequential ablations (P = .0001). Larger and more circular ablations were achieved with three antennas compared with two antennas (P < .05). Ablations were generally smaller in vivo compared with ex vivo.

      CONCLUSION: The use of multiple antennas and simultaneous power delivery creates larger, more confluent ablations with greater temperatures than those created with sequential power delivery.

      PMID:26133361 | PMC:PMC4699493 | DOI:10.1148/radiol.2015142151

      View details for PubMedID 26133361

Contact Information

Colin Harari, MD

600 Highland Avenue,
Madison , WI 53792