Shuang (George) Zhao

Shuang (George) Zhao, MD

Assistant Professor

Department of Human Oncology

I am an assistant professor in the Department of Human Oncology. I completed my bachelor’s and master’s degrees in Computer Science & Engineering with a focus on Intelligent Systems at the University of Michigan. I then completed my MD at the University of Michigan Medical School. After a transitional year internship at Beaumont Hospital – Dearborn, I returned to the University of Michigan for residency training in radiation oncology. Under the American Board of Radiology’s Holman Pathway, I led multiple cancer genomics and biomarker studies under the mentorship of Dr. Felix Feng. As a physician-scientist, my clinical focus is on the treatment of patients with GU malignancies. My independent translational research laboratory focuses on using advances in sequencing and computational techniques to develop biomarkers of treatment response and resistance, primarily in prostate cancer. I co-direct the UWCCC Circulating Biomarker Core with Dr. Josh Lang, where we work on translating liquid biopsy technology into the clinic.

Education

Residency, University of Michigan, Radiation Oncology (2020)

MD, University of Michigan, Medicine (2015)

MSE, University of Michigan, Computer Science and Engineering (2010)

BSE, University of Michigan, Computer Science and Engineering (2009)

Academic Appointments

Assistant Professor, Human Oncology (2020)

Co-director, University of Wisconsin Carbone Cancer Center Circulating Biomarker Core (2020)

Selected Honors and Awards

Roentgen Resident/Fellow Research Award (2020)

Radiation Research Society Scholar-in-Training Travel Award (2018)

MRS Resident Conference & Research Forum Radiation Oncology Abstract Award (2017)

ASTRO Resident Clinical/Basic Science Research Award in Biology (2015)

Dean’s Merit Scholarship, University of Michigan Medical School (2010-15)

William L. Everitt Award of Excellence, University of Michigan (2009)

James B. Angell Scholar, University of Michigan (2009)

Engineering Scholarship of Honor, University of Michigan (2005-09)

Pfizer Corporate Merit Scholarship, National Merit Scholarship Corporation (2005-09 )

Michigan Merit Award, State of Michigan (2005)

Regents Merit Scholarship, University of Michigan (2005)

Research Focus

GU malignancies

Biomarkers to personalize treatment in cancer 

In the Zhao Lab, we focus on developing novel clinical biomarkers that predict response and resistance to specific therapies across cancers. These biomarkers can be used to better select which patients derive a benefit from treatment, which patients do not and can be spared potential toxicity, as well as monitor for emergence of resistance. We seek to use advanced computational approaches and liquid biopsy technologies to better personalize the care of cancer patients.

Predictive biomarkers

Treatment decisions for cancer has historically been based on tissue of origin and other pathologic and clinical variables which give prognostic information on the overall level of aggressiveness of a tumor. Predictive biomarkers on the other hand are used to predict response to specific treatments, rather than overall prognosis. Such biomarkers have high clinical utility in deciding the optimal treatment approach for an individual patient. Our laboratory seeks to leverage advances in molecular medicine to identify new predictive biomarkers for standard and emerging cancer therapies.

predictive biomarkers graphs

  • SG Zhao*, SL Chang*, DE Spratt, N Erho, M Yu, HA Ashab, M Alshalalfa, C Speers, SA Tomlins, E Davicioni, AP Dicker, PR Carroll, MR Cooperberg, SJ Freedland, RJ Karnes, A Ross, EM Schaeffer, RB Den, PL Nguyen†, FY Feng†. The development and validation of a 24-gene predictor of response to post-operative radiation therapy in prostate cancer: a matched retrospective analysis. Lancet Oncology. PMID 27743920.
  • SG Zhao*, SL Chang*, N Erho, M Yu, J Lehrer, M Alshalalfa, C Speers, MR Cooperberg, W Kim, CJ Ryan, RB Den, SJ Freedland, E Posadas, H Sandler, EA Klein, P Black, R Seiler, SA Tomlins, AM Chinnaiyan MD, RB Jenkins, E Davicioni, AE Ross, EM Schaeffer, PL Nguyen, PR Carroll, RJ Karnes, DE Spratt†, FY Feng†. Associations of luminal and basal subtyping of prostate cancer with prognosis and response to androgen deprivation therapy. JAMA Oncology. PMID 28494073.
  • SG Zhao, M Yu, DE Spratt, SL Chang, FY Feng, MM Kim, CW Speers, BL Carlson, AC Mladek, TS Lawrence, JN Sarkaria, DR Wahl. Development and validation of xenograft-based platform-independent gene signatures that predict response to alkylating chemotherapy, radiation, and combination therapy in patients with glioblastoma. Neuro-Oncology. PMID 31121035.
  • NM White*, SG Zhao*, J Zhang, EB Rozycki, HX Dang, SD McFadden, AM Eteleeb, M Alshalalfa, IA Vergara, N Erho, JM Arbeitg, RJ Karnes, RB Den, E Davicioni, CA Maher. Multi-institutional analysis shows low PCAT-14 expression associates with poor outcome in prostate cancer. European Urology. PMID 27460352.
  • R Aggarwal*, NR Rydzewski*, L Zhang, A Foye, W Kim, KT Helzer, H Bakhtiar, SL Chang, MD Perry, M Gleave, RE Reiter, J Huang, CP Evans, JJ Alumkal, JM Lang, M Yu, DA Quigley, M Sjöström, EJ Small, FY Feng, SG Zhao. Prognosis associated with luminal and basal subtypes of metastatic prostate cancer. JAMA Oncology. PMID 34554200.

clinical next-generation sequencing

Integrated multi-omic next-generation sequencing (NGS) on clinical samples allows for a global view of the landscape of molecular alterations that drive cancer progression and treatment resistance. Our lab analyzes correlative sequencing data from clinical cohorts and trials to better understand the molecular underpinnings of the phenotypic behavior of tumors.

  • SG Zhao*, W Chen*, H Li*, A Foye, M Zhang, M Sjöstrjöm, R Aggarwal, D Playdle, A Liao, JJ Alumkal, R Das, J Chou, JT Hua, TJ Barnard, AM Bailey, E Chow, M Perry, HX Dang, R Yang, R Moussavi-Baygi, L Zhang, M Alshalalfa, SL Chang, KE Houlahan, YJ Shiah, TM Beer, G Thomas, KN Chi, M Gleave, A Zoubeidi, RE Reiter, MB Rettig, O Witte, Y Kim, L Fong, DE Spratt, TM Morgan, R Bose, FW Huang, H Li, L Chesner, T Shenoy, H Goodazi, IA Asangani, S Sandhu, JM Lang, PN Lara, N Mahajan, CP Evans, P Febbo, S Batzoglou, KE Knudsen, HH He, J Huang, W Zwart, JF Costello, J Luo, SA Tomlins, AW Wyatt, SM Dehm, A Ashworth, LA Gilbert, P Boutros, K Farh, AM Chinnaiyan†, CA Maher†, EJ Small†, DA Quigley†, FY Feng†. Hallmarks of epigenomic regulation in advanced prostate cancer. Nature Genetics. PMID 32661416.
  • DA Quigley*, HX Dang*, SG Zhao*, P Lloyd, R Aggarwal, JJ Alumkal, A Foye, V Kothari, M Perry, AM Bailey, D Playdle, TJ Barnard, L Zhang, J Zhang, JF Youngren, MP Cieslik, A Parolia, TM Beer, G Thomas, KN Chi, M Gleave, N Lack, A Zoubeidi, RE Reiter, M Rettig, O Witte, CJ Ryan, L Fong, W Kim, T Friedlander, J Chou, H Li, R Das, H Li, R Moussavi-Baygi, H Goodarzi, LA Gilbert, P Lara, CP Evans, TC Goldstein, JM Stuart, SA Tomlins, DE Spratt, RK Cheetham, DT Cheng, K Farh, JS Gehring, J Hakenberg, A Liao, P Febbo, J Shon, S Batzoglou, KE Knudsen, HH He, J Huang, AW Wyatt, SM Dehm, A Ashworth, AM Chinnaiyan†, CA Maher†, EJ Small†, FY Feng†. Genomic hallmarks and structural variation in metastatic prostate cancer. Cell. PMID 30033370.
  • SG Zhao*, WS Chen*, R Das, SL Chang, SA Tomlins, J Chou, DA Quigley, H Dang, T Barnard, BA Mahal, EA Gibb, Y Liu, E Davicioni, LR Duska, E Posadas, S Jolly, DE Spratt, PL Nguyen, CA Maher, EJ Small, FY Feng. Clinical and genomic implications of luminal and basal subtypes across carcinomas. Clinical Cancer Research. PMID 30573691.
  • E Feng*, NR Rydzewski*, M Zhang, A Lundberg, M Bootsma, KT Helzer, JM Lang, R Aggarwal, EJ Small, DA Quigley, M Sjöström, SG Zhao. Intrinsic molecular subtypes of metastatic castration-resistant prostate cancer. Clinical Cancer Research. In press. PMID 36260524.

Computational approaches

High-throughput sequencing techniques can generate an enormous amount of data. Machine-learning is the branch of computer science specifically focused on identifying important patterns in that are too complex for humans to independently explore. Our laboratory seeks to leverage machine learning and other advanced computational approaches to develop models for clinical and biological endpoints.

  • SG Zhao, J Lehrer, SL Chang, R Das, N Erho, Y Liu, M Sjöström, RB Den, SJ Freedland, EA Klein, RJ Karnes, EM Schaeffer, M Xu, C Speers, PL Nguyen, AE Ross, JM Chan, MR Cooperberg, PR Carroll, E Davicioni, L Fong, DE Spratt, FY Feng. The immune landscape of prostate cancer and nomination of PD-L2 as a potential therapeutic target. J Natl Cancer Inst. PMID 30321406.
  • SG Zhao*, JR Evans*, V Kothari, G Sun, A Larm, V Mondine, EM Schaeffer, AE Ross, EA Klein, RB Den, AP Dicker, RJ Karnes, N Erho, PL Nguyen, E Davicioni, FY Feng. The landscape of prognostic outlier genes in high-risk prostate cancer. Clinical Cancer Research. PMID 26631616.
  • JR Evans*, SG Zhao*, SL Chang, SA Tomlins, N Erho, A Sboner, MJ Schiewer, DE Spratt, V Kothari, EA Klein, RB Den, AP Dicker, RJ Karnes, X Yu, PL Nguyen, MA Rubin, J de Bono, KE Knudsen, E Davicioni, FY Feng. Patient-level DNA damage and repair pathway profiles and prognosis after prostatectomy for High-Risk Prostate Cancer. JAMA Oncology. PMID 26746117.
  • C Speers*, S Zhao*, H Bartelink, M Liu, LJ Pierce†, FY Feng†. Development and validation of a novel radiosensitivity signature in human breast cancer. Clinical Cancer Research. PMID 25904749.
  • NR Rydzewski, E Peterson, JM Lang, M Yu, SL Chang, M Sjöström, H Bakhtiar, G Song, KT Helzer, ML Bootsma, WS Chen, RM Shrestha, M Zhang, DA Quigley, R Aggarwal, EJ Small, DR Wahl, FY Feng†, SG Zhao†. Predicting Cancer Drug TARGETS – TreAtment Response Generalized Elastic-neT Signatures. NPJ Genom Med. PMID 34548481.
  • H Bakhtiar*, KT Helzer*, Y Park, Y Chen, NR Rydzewski, ML Bootsma, Y Shi, PM Harari, M Sharifi, M Sjöström, JM Lang, M Yu, SG Zhao. Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone. NPJ Genom Med. PMID 36253482.

Liquid Biomarkers

Obtaining tissue specimens from cancer patients for molecular analysis is logistically challenging to perform at scale, especially in metastatic cancer. In collaboration with the UWCCC Circulating Biomarker Core, we work on developing liquid biopsy approaches for circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and other non-invasively assays.

Figure showing data results.

  • JM Sperger*, H Emamekhoo*, RR McKay*, CN Stahlfeld, A Singh, XE Chen, L Kwak, CS Gilsdorf, SK Wolfe, XX Wei, R Silver, Z Zhang, MJ Morris, G Bubley, FY Feng, HI Scher, D Rathkopf, SM Dehm, TK Choueiri, S Halabi, AJ Armstrong, AW Wyatt, ME Taplin, SG Zhao, JM Lang. Prospective evaluation of clinical outcomes utilizing a multi-plex liquid biopsy targeting diverse resistance mechanisms in metastatic prostate cancer. J Clin Oncol. PMID 34197212.
  • M Bootsma*, RR McKay*, H Emamekhoo*, RM Bade, JL Schehr, MC Mannino, A Singh, SK Wolfe, ZD Schultz, J Sperger, W Xie, S Signoretti, CE Kyriakopoulos, D Kosoff, EJ Abel, KT Helzer, N Rydzewski, H Bakhtiar, Y Shi, G Blitzer, M Bassetti, J Floberg, M Yu, N Sethakorn, M Sharifi, PM Harari, TK Choueiri, JM Lang, SG Zhao. Longitudinal molecular profiling of circulating tumor cells in metastatic renal cell carcinoma. J Clin Oncol. PMID 35617646.
  • JR Prensner*, S Zhao*, N Erho, M Schipper, MK Iyer, SM Dhanasekaran, C Magi-Galluzzi, R Mehra, A Sahu, J Siddiqui, E Davicioni, RB Den, AP Dicker, RJ Karnes, JT Wei, EA Klein, RB Jenkins, AM Chinnaiyan, FY Feng. RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1. Lancet Oncology. PMID 25456366.
  • SG Zhao*, JM Sperger*, JL Schehr*, RR McKay, H Emamekhoo, A Singh, ZD Schultz, RM Bade, CN Stahlfeld, CS Gilsdorf, CI Hernandez, SK Wolfe, RD Mayberry, HM Krause, M Bootsma, KT Helzer, N Rydzewski, H Bakhtiar, Y Shi, G Blitzer, CE Kyriakopoulos, D Kosoff, XX Wei, J Floberg, N Sethakorn, M Sharifi, PM Harari, W Huang, H Beltran, TK Choueiri, HI Scher, DE Rathkopf, S Halabi, AJ Armstrong, DJ Beebe, M Yu, KE Sundling, ME Taplin, JM Lang. A clinical-grade liquid biomarker to detect neuroendocrine differentiation in prostate cancer. J Clin Invest. 2022 Nov 1;132(21). PMID 36317634.
  • M Sjöström*, SG Zhao*, S Levy*, M Zhang*, Y Ning, R Shrestha, A Lundberg, C Herberts, A Foye, R Aggarwal, JT Hua, H Li, A Bergamaschi, C Maurice-Dror, A Maheshwari, S Chen, SWS Ng, W Ye, J Petricca, M Fraser, L Chesner, MD Perry, T Moreno-Rodriguez, WS Chen, JJ Alumkal, J Chou, AK Morgans, TM Beer, GV Thomas, M Gleave, P Lloyd, T Phillips, E McCarthy, MC Haffner, A Zoubeidi, M Annala, RE Reiter, MB Rettig, O Witte, L Fong, R Bose, FW Huang, J Luo, A Bjartell, JM Lang, NP Mahajan, PN Lara, CP Evans, PT Tran, EM Posadas, C He, X Cui, J Huang, W Zwart, LA Gilbert, CA Maher, PC Boutros, KN Chi, A Ashworth, EJ Small, HH He, AW Wyatt, DA Quigley, FY Feng. The 5-hydroxymethylcytosine landscape of prostate cancer. Cancer Research. 2022 Nov 2;82(21):3888-3902. PMID 36251389.

*Co-first authorship, †Co-senior authorship

Funding

  • Prostate Cancer Foundation Young Investigator Award (Principal Investigator)
  • DoD Prostate Cancer Research Program Translational Science Award (Partnering Principal Investigator)
  • DoD Prostate Cancer Research Program Physician Research Award (Principal Investigator)
  • DoD Prostate Cancer Research Program Idea Award (Principal Investigator)
  • NIH DP2 Director’s New Innovator Award (Principal Investigator)
  • NCCN Young Investigator Award (Principal Investigator)
  • A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer The Journal of clinical investigation
    Zhao SG, Sperger JM, Schehr JL, McKay RR, Emamekhoo H, Singh A, Schultz ZD, Bade RM, Stahlfeld CN, Gilsdorf CS, Hernandez CI, Wolfe SK, Mayberry RD, Krause HM, Bootsma M, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Kyriakopoulos CE, Kosoff D, Wei XX, Floberg J, Sethakorn N, Sharifi M, Harari PM, Huang W, Beltran H, Choueiri TK, Scher HI, Rathkopf DE, Halabi S, Armstrong AJ, Beebe DJ, Yu M, Sundling KE, Taplin M, Lang JM
    2022 Nov 1;132(21):e161858. doi: 10.1172/JCI161858.
  • Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Feng E, Rydzewski NR, Zhang M, Lundberg A, Bootsma M, Helzer KT, Lang JM, Aggarwal R, Small EJ, Quigley DA, Sjöström M, Zhao SG
    2022 Oct 19:CCR-22-2567. doi: 10.1158/1078-0432.CCR-22-2567. Online ahead of print.
  • Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone NPJ genomic medicine
    Bakhtiar H, Helzer KT, Park Y, Chen Y, Rydzewski NR, Bootsma ML, Shi Y, Harari PM, Sharifi M, Sjöström M, Lang JM, Yu M, Zhao SG
    2022 Oct 17;7(1):58. doi: 10.1038/s41525-022-00328-7.
    • More

      PMID:36253482 | PMC:PMC9576758 | DOI:10.1038/s41525-022-00328-7


      View details for PubMedID 36253482
  • The 5-Hydroxymethylcytosine Landscape of Prostate Cancer Cancer research
    Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng WS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui X, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY
    2022 Nov 2;82(21):3888-3902. doi: 10.1158/0008-5472.CAN-22-1123.
  • Radiomic Modeling of Bone Density and Rib Fracture Risk After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer Advances in radiation oncology
    Rydzewski NR, Yadav P, Musunuru HB, Condit KM, Francis D, Zhao SG, Baschnagel AM
    2021 Dec 29;7(3):100884. doi: 10.1016/j.adro.2021.100884. eCollection 2022 May-Jun.
    • More

      PMID:35647405 | PMC:PMC9133372 | DOI:10.1016/j.adro.2021.100884


      View details for PubMedID 35647405
  • Longitudinal Molecular Profiling of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Bootsma M, McKay RR, Emamekhoo H, Bade RM, Schehr JL, Mannino MC, Singh A, Wolfe SK, Schultz ZD, Sperger J, Xie W, Signoretti S, Kyriakopoulos CE, Kosoff D, Abel EJ, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Bassetti M, Floberg J, Yu M, Sethakorn N, Sharifi M, Harari PM, Choueiri TK, Lang JM, Zhao SG
    2022 Nov 1;40(31):3633-3641. doi: 10.1200/JCO.22.00219. Epub 2022 May 26.
  • A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer Molecular cancer
    Fletcher CE, Deng L, Orafidiya F, Yuan W, Lorentzen GS, Cyran OW, Varela-Carver A, Constantin TA, Leach DA, Dobbs FM, Figueiredo I, Gurel B, Parkes E, Bogdan D, Pereira RR, Zhao SG, Neeb A, Issa F, Hester J, Kudo H, Liu Y, Philippou Y, Bristow R, Knudsen K, Bryant RJ, Feng FY, Reed SH, Mills IG, Bono Jd, Bevan CL
    2022 Mar 22;21(1):82. doi: 10.1186/s12943-022-01540-w.
    • More

      PMID:35317841 | PMC:PMC8939142 | DOI:10.1186/s12943-022-01540-w


      View details for PubMedID 35317841
  • SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples Clinical epigenetics
    Rodems TS, Juang DS, Stahlfeld CN, Gilsdorf CS, Krueger EG, Heninger E, Zhao SG, Sperger JM, Beebe DJ, Haffner MC, Lang JM
    2022 Mar 10;14(1):37. doi: 10.1186/s13148-022-01252-4.
    • More

      PMID:35272673 | PMC:PMC8908705 | DOI:10.1186/s13148-022-01252-4


      View details for PubMedID 35272673
  • Reply to M. K. Bos et al Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Sperger JM, Feng FY, Armstrong AJ, Zhao SG, Lang JM
    2022 Feb 10;40(5):520-522. doi: 10.1200/JCO.21.02238. Epub 2021 Dec 8.
  • Prostate cancer research in the 21st century; report from the 2021 Coffey-Holden prostate cancer academy meeting The Prostate
    Miyahira AK, Zarif JC, Coombs CC, Flavell RR, Russo JW, Zaidi S, Zhao D, Zhao SG, Pienta KJ, Soule HR
    2022 Feb;82(2):169-181. doi: 10.1002/pros.24262. Epub 2021 Nov 3.
  • Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer JAMA oncology
    Aggarwal R, Rydzewski NR, Zhang L, Foye A, Kim W, Helzer KT, Bakhtiar H, Chang SL, Perry MD, Gleave M, Reiter RE, Huang J, Evans CP, Alumkal JJ, Lang JM, Yu M, Quigley DA, Sjöström M, Small EJ, Feng FY, Zhao SG
    2021 Nov 1;7(11):1644-1652. doi: 10.1001/jamaoncol.2021.3987.
    • More

      PMID:34554200 | PMC:PMC8461554 | DOI:10.1001/jamaoncol.2021.3987


      View details for PubMedID 34554200
  • Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE) Cancer genetics
    Swami N, Hwang WL, Guo JA, Hoffman H, Abramowitz MC, Elbakouny Z, Beltran H, Chipidza F, Choueiri T, Pra AD, Huang F, Kaochar S, Kantoff P, Kim DW, Kishan AU, Kobetz E, Marinac C, Mucci LA, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG, Rebbeck TR, Nguyen PL, Feng FY, Mahal BA, Alshalalfa M
    2021 Nov;258-259:61-68. doi: 10.1016/j.cancergen.2021.08.004. Epub 2021 Aug 28.
  • Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures NPJ genomic medicine
    Rydzewski NR, Peterson E, Lang JM, Yu M, Chang SL, Sjöström M, Bakhtiar H, Song G, Helzer KT, Bootsma ML, Chen WS, Shrestha RM, Zhang M, Quigley DA, Aggarwal R, Small EJ, Wahl DR, Feng FY, Zhao SG
    2021 Sep 21;6(1):76. doi: 10.1038/s41525-021-00239-z.
    • More

      PMID:34548481 | PMC:PMC8455625 | DOI:10.1038/s41525-021-00239-z


      View details for PubMedID 34548481
  • ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts Molecular cancer therapeutics
    Baschnagel AM, Elnaggar JH, VanBeek HJ, Kromke AC, Skiba JH, Kaushik S, Abel L, Clark PA, Longhurst CA, Nickel KP, Leal TA, Zhao SG, Kimple RJ
    2021 Nov;20(11):2129-2139. doi: 10.1158/1535-7163.MCT-21-0305. Epub 2021 Aug 19.
    • More

      PMID:34413128 | PMC:PMC8571002 | DOI:10.1158/1535-7163.MCT-21-0305


      View details for PubMedID 34413128
  • Prospective Evaluation of Clinical Outcomes Using a Multiplex Liquid Biopsy Targeting Diverse Resistance Mechanisms in Metastatic Prostate Cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Sperger JM, Emamekhoo H, McKay RR, Stahlfeld CN, Singh A, Chen XE, Kwak L, Gilsdorf CS, Wolfe SK, Wei XX, Silver R, Zhang Z, Morris MJ, Bubley G, Feng FY, Scher HI, Rathkopf D, Dehm SM, Choueiri TK, Halabi S, Armstrong AJ, Wyatt AW, Taplin M, Zhao SG, Lang JM
    2021 Sep 10;39(26):2926-2937. doi: 10.1200/JCO.21.00169. Epub 2021 Jul 1.
  • Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance Clinical cancer research : an official journal of the American Association for Cancer Research
    McKay RR, Kwak L, Crowdis JP, Sperger JM, Zhao SG, Xie W, Werner L, Lis RT, Zhang Z, Wei XX, Lang JM, Van Allen M, Bhatt RS, Yu EY, Nelson PS, Bubley GJ, Montgomery RB, Taplin M
    2021 Jul 1;27(13):3610-3619. doi: 10.1158/1078-0432.CCR-20-4616. Epub 2021 Apr 13.
    • More

      PMID:33849963 | PMC:PMC8254786 | DOI:10.1158/1078-0432.CCR-20-4616


      View details for PubMedID 33849963
  • Prostate-specific Membrane Antigen and Fluciclovine Transporter Genes are Associated with Variable Clinical Features and Molecular Subtypes of Primary Prostate Cancer European urology
    Chu CE, Alshalalfa M, Sjöström M, Zhao SG, Liu Y, Chou J, Herlemann A, Mahal B, Kishan AU, Spratt DE, Cooperberg M, Small E, Wong A, Porten S, Hope TA, Ross AE, Davicioni E, Nguyen P, Karnes RJ, Carroll PR, Schaeffer E, Feng FY
    2021 Jun;79(6):717-721. doi: 10.1016/j.eururo.2021.03.017. Epub 2021 Apr 8.
  • Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer European urology
    Kumaraswamy A, Leng RW, Westbrook TC, Yates JA, Zhao SG, Evans CP, Feng FY, Morgan TM, Alumkal JJ
    2021 Jul;80(1):71-81. doi: 10.1016/j.eururo.2021.03.005. Epub 2021 Mar 27.
    • More

      PMID:33785255 | PMC:PMC8547521 | DOI:10.1016/j.eururo.2021.03.005


      View details for PubMedID 33785255
  • Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial JAMA oncology
    Feng FY, Huang H, Spratt DE, Zhao SG, Sandler HM, Simko JP, Davicioni E, Nguyen PL, Pollack A, Efstathiou JA, Dicker AP, Todorovic T, Margrave J, Liu YS, Dabbas B, Thompson JS, Das R, Dignam JJ, Sweeney C, Attard G, Bahary J, Lukka HR, Hall WA, Pisansky TM, Shah AB, Pugh SL, Shipley WU, Tran PT
    2021 Apr 1;7(4):544-552. doi: 10.1001/jamaoncol.2020.7671.
    • More

      PMID:33570548 | PMC:PMC7879385 | DOI:10.1001/jamaoncol.2020.7671


      View details for PubMedID 33570548
  • Novel Transcriptomic Interactions Between Immune Content and Genomic Classifier Predict Lethal Outcomes in High-grade Prostate Cancer European urology
    Yamoah K, Awasthi S, Mahal BA, Zhao SG, Grass GD, Berglund A, Abraham-Miranda J, Gerke T, Rounbehler RJ, Davicioni E, Liu Y, Park J, Cleveland JL, Pow-Sang JM, Fernandez D, Torres-Roca J, Karnes RJ, Schaeffer E, Freedland SJ, Spratt DE, Den RB, Rebbeck TR, Feng F
    2022 Apr;81(4):325-330. doi: 10.1016/j.eururo.2020.11.038. Epub 2020 Dec 7.
  • A Systematic Review of the Evidence for the Decipher Genomic Classifier in Prostate Cancer European urology
    Jairath NK, Pra AD, Vince R, Dess RT, Jackson WC, Tosoian JJ, McBride SM, Zhao SG, Berlin A, Mahal BA, Kishan AU, Den RB, Freedland SJ, Salami SS, Kaffenberger SD, Pollack A, Tran P, Mehra R, Morgan TM, Weiner AB, Mohamad O, Carroll PR, Cooperberg MR, Karnes RJ, Nguyen PL, Michalski JM, Tward JD, Feng FY, Schaeffer EM, Spratt DE
    2021 Mar;79(3):374-383. doi: 10.1016/j.eururo.2020.11.021. Epub 2020 Dec 5.
  • SV-HotSpot: detection and visualization of hotspots targeted by structural variants associated with gene expression Scientific reports
    Eteleeb AM, Quigley DA, Zhao SG, Pham D, Yang R, Dehm SM, Luo J, Feng FY, Dang HX, Maher CA
    2020 Sep 28;10(1):15890. doi: 10.1038/s41598-020-71168-7.
    • More

      PMID:32985524 | PMC:PMC7522247 | DOI:10.1038/s41598-020-71168-7


      View details for PubMedID 32985524
  • Autoantibody Landscape in Patients with Advanced Prostate Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Chen WS, Haynes WA, Waitz R, Kamath K, Vega-Crespo A, Shrestha R, Zhang M, Foye A, Carretero IB, Garcilazo IP, Zhang M, Zhao SG, Sjöström M, Quigley DA, Chou J, Beer TM, Rettig M, Gleave M, Evans CP, Lara P, Chi KN, Reiter RE, Alumkal JJ, Ashworth A, Aggarwal R, Small EJ, Daugherty PS, Ribas A, Oh DY, Shon JC, Feng FY
    2020 Dec 1;26(23):6204-6214. doi: 10.1158/1078-0432.CCR-20-1966. Epub 2020 Sep 23.
    • More

      PMID:32967941 | PMC:PMC7710628 | DOI:10.1158/1078-0432.CCR-20-1966


      View details for PubMedID 32967941
  • Purine metabolism regulates DNA repair and therapy resistance in glioblastoma Nature communications
    Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, Umemura Y, Walker AK, Kachman M, Sarkaria JN, Xiong J, Morgan MA, Rehemtualla A, Castro MG, Lowenstein P, Chandrasekaran S, Lawrence TS, Lyssiotis CA, Wahl DR
    2020 Jul 30;11(1):3811. doi: 10.1038/s41467-020-17512-x.
    • More

      PMID:32732914 | PMC:PMC7393131 | DOI:10.1038/s41467-020-17512-x


      View details for PubMedID 32732914
  • The DNA methylation landscape of advanced prostate cancer Nature genetics
    Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Chang SL, Houlahan KE, Shiah Y, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Kim MY, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY
    2020 Aug;52(8):778-789. doi: 10.1038/s41588-020-0648-8. Epub 2020 Jul 13.
  • Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-Enriched Subtypes Journal of clinical medicine
    Jairath NK, Farha MW, Srinivasan S, Jairath R, Green MD, Dess RT, Jackson WC, Weiner AB, Schaeffer EM, Zhao SG, Feng FY, Naqa IE, Spratt DE
    2020 Jun 24;9(6):1973. doi: 10.3390/jcm9061973.
  • A Signature That May Be Predictive of Early Versus Late Recurrence After Radiation Treatment for Breast Cancer That May Inform the Biology of Early, Aggressive Recurrences International journal of radiation oncology, biology, physics
    Speers C, Chang SL, Pesch A, Ritter C, Olsen E, Chandler B, Moubadder L, Liu M, Cameron M, Michmerhuizen A, Wilder-Romans K, Zhao SG, Nyati S, Bartelink H, Feng FY, Pierce LJ
    2020 Nov 1;108(3):686-696. doi: 10.1016/j.ijrobp.2020.05.015. Epub 2020 May 17.
  • Performance of clinicopathologic models in men with high risk localized prostate cancer: impact of a 22-gene genomic classifier Prostate cancer and prostatic diseases
    Tosoian JJ, Birer SR, Karnes RJ, Zhang J, Davicioni E, Klein EE, Freedland SJ, Weinmann S, Trock BJ, Dess RT, Zhao SG, Jackson WC, Yamoah K, Pra AD, Mahal BA, Morgan TM, Mehra R, Kaffenberger S, Salami SS, Kane C, Pollack A, Den RB, Berlin A, Schaeffer EM, Nguyen PL, Feng FY, Spratt DE
    2020 Dec;23(4):646-653. doi: 10.1038/s41391-020-0226-2. Epub 2020 Mar 30.
  • Genomic and clinical characterization of stromal infiltration markers in prostate cancer Cancer
    Mahal BA, Alshalalfa M, Zhao SG, Beltran H, Chen WS, Chipidza F, Davicioni E, Karnes RJ, Ku S, Lotan TL, Muralidhar V, Rebbeck TR, Schaeffer EM, Spratt DE, Feng FY, Nguyen PL
    2020 Apr 1;126(7):1407-1412. doi: 10.1002/cncr.32688. Epub 2020 Jan 6.
  • Prostate cancer incidence across stage, NCCN risk groups, and age before and after USPSTF Grade D recommendations against prostate-specific antigen screening in 2012 Cancer
    Butler SS, Muralidhar V, Zhao SG, Sanford NN, Franco I, Fullerton ZH, Chavez J, D'Amico AV, Feng FY, Rebbeck TR, Nguyen PL, Mahal BA
    2020 Feb 15;126(4):717-724. doi: 10.1002/cncr.32604. Epub 2019 Dec 3.
  • Germline polymorphisms associated with impaired survival outcomes and somatic tumor alterations in advanced prostate cancer Prostate cancer and prostatic diseases
    Chen WS, Feng EL, Aggarwal R, Foye A, Beer TM, Alumkal JJ, Gleave M, Chi KN, Reiter RE, Rettig MB, Evans CP, Small EJ, Sharifi N, Zhao SG
    2020 Jun;23(2):316-323. doi: 10.1038/s41391-019-0188-4. Epub 2019 Nov 19.
  • Clinicogenomic Radiotherapy Classifier Predicting the Need for Intensified Locoregional Treatment After Breast-Conserving Surgery for Early-Stage Breast Cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Sjöström M, Chang SL, Fishbane N, Davicioni E, Zhao SG, Hartman L, Holmberg E, Feng FY, Speers CW, Pierce LJ, Malmström P, Fernö M, Karlsson P
    2019 Dec 10;37(35):3340-3349. doi: 10.1200/JCO.19.00761. Epub 2019 Oct 16.
  • Transcriptomic Heterogeneity of Androgen Receptor Activity Defines a <em>de novo</em> low AR-Active Subclass in Treatment Naïve Primary Prostate Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Spratt DE, Alshalalfa M, Fishbane N, Weiner AB, Mehra R, Mahal BA, Lehrer J, Liu Y, Zhao SG, Speers C, Morgan TM, Dicker AP, Freedland SJ, Karnes RJ, Weinmann S, Davicioni E, Ross AE, Den RB, Nguyen PL, Feng FY, Lotan TL, Chinnaiyan AM, Schaeffer EM
    2019 Nov 15;25(22):6721-6730. doi: 10.1158/1078-0432.CCR-19-1587. Epub 2019 Sep 12.
    • More

      PMID:31515456 | PMC:PMC6858964 | DOI:10.1158/1078-0432.CCR-19-1587


      View details for PubMedID 31515456
  • DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway Clinical cancer research : an official journal of the American Association for Cancer Research
    Kothari V, Goodwin JF, Zhao SG, Drake JM, Yin Y, Chang SL, Evans JR, Wilder-Romans K, Gabbara K, Dylgjeri E, Chou J, Sun G, Tomlins SA, Mehra R, Hege K, Filvaroff EH, Schaeffer EM, Karnes RJ, Quigley DA, Rathkopf DE, He HH, Speers C, Spratt DE, Gilbert LA, Ashworth A, Chinnaiyan AM, Raj GV, Knudsen KE, Feng FY
    2019 Sep 15;25(18):5608-5622. doi: 10.1158/1078-0432.CCR-18-2387. Epub 2019 Jul 2.
    • More

      PMID:31266829 | PMC:PMC6744969 | DOI:10.1158/1078-0432.CCR-18-2387


      View details for PubMedID 31266829
  • Conservative management of low-risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database Cancer
    Mahal AR, Butler S, Franco I, Muralidhar V, Larios D, Pike RG, Zhao SG, Sanford NN, Dess RT, Feng FY, D'Amico AV, Spratt DE, Yu JB, Nguyen PL, Rebbeck TR, Mahal BA
    2019 Oct 1;125(19):3338-3346. doi: 10.1002/cncr.32332. Epub 2019 Jun 28.
  • Transcriptomic and Clinical Characterization of Neuropeptide Y Expression in Localized and Metastatic Prostate Cancer: Identification of Novel Prostate Cancer Subtype with Clinical Implications European urology oncology
    Alshalalfa M, Nguyen PL, Beltran H, Chen WS, Davicioni E, Zhao SG, Rebbeck TR, Schaeffer EM, Lotan TL, Feng FY, Mahal BA
    2019 Jul;2(4):405-412. doi: 10.1016/j.euo.2019.05.001. Epub 2019 Jun 2.
  • Xenograft-based, platform-independent gene signatures to predict response to alkylating chemotherapy, radiation, and combination therapy for glioblastoma Neuro-oncology
    Zhao SG, Yu M, Spratt DE, Chang SL, Feng FY, Kim MM, Speers CW, Carlson BL, Mladek AC, Lawrence TS, Sarkaria JN, Wahl DR
    2019 Sep 6;21(9):1141-1149. doi: 10.1093/neuonc/noz090.
  • Active Surveillance for Low-Risk Prostate Cancer in Black Patients The New England journal of medicine
    Butler S, Muralidhar V, Chavez J, Fullerton Z, Mahal A, Nezolosky M, Vastola M, Zhao SG, D'Amico AV, Dess RT, Feng FY, King MT, Mouw KW, Spratt DE, Trinh Q, Nguyen PL, Rebbeck TR, Mahal BA
    2019 May 23;380(21):2070-2072. doi: 10.1056/NEJMc1900333.
  • Impact of Biochemical Failure After Salvage Radiation Therapy on Prostate Cancer-specific Mortality: Competition Between Age and Time to Biochemical Failure European urology oncology
    Jackson WC, Suresh K, Tumati V, Dess RT, Soni PD, Zhao SG, Zumsteg ZS, Hannan R, Hollenbeck BK, George A, Kaffenberger SD, Salami SS, Hearn WD, Morgan TM, Mehra R, Schipper M, Feng FY, Desai NB, Spratt DE
    2018 Sep;1(4):276-282. doi: 10.1016/j.euo.2018.04.014. Epub 2018 Sep 28.
  • Novel RB1-Loss Transcriptomic Signature Is Associated with Poor Clinical Outcomes across Cancer Types Clinical cancer research : an official journal of the American Association for Cancer Research
    Chen WS, Alshalalfa M, Zhao SG, Liu Y, Mahal BA, Quigley DA, Wei T, Davicioni E, Rebbeck TR, Kantoff PW, Maher CA, Knudsen KE, Small EJ, Nguyen PL, Feng FY
    2019 Jul 15;25(14):4290-4299. doi: 10.1158/1078-0432.CCR-19-0404. Epub 2019 Apr 22.
    • More

      PMID:31010837 | PMC:PMC7883384 | DOI:10.1158/1078-0432.CCR-19-0404


      View details for PubMedID 31010837
  • Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer European urology
    Chen WS, Aggarwal R, Zhang L, Zhao SG, Thomas GV, Beer TM, Quigley DA, Foye A, Playdle D, Huang J, Lloyd P, Lu E, Sun D, Guan X, Rettig M, Gleave M, Evans CP, Youngren J, True L, Lara P, Kothari V, Xia Z, Chi KN, Reiter RE, Maher CA, Feng FY, Small EJ, Alumkal JJ, Team CD
    2019 Nov;76(5):562-571. doi: 10.1016/j.eururo.2019.03.020. Epub 2019 Mar 28.
    • More

      PMID:30928160 | PMC:PMC6764911 | DOI:10.1016/j.eururo.2019.03.020


      View details for PubMedID 30928160
  • MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer Prostate cancer and prostatic diseases
    Nickols NG, Nazarian R, Zhao SG, Tan V, Uzunangelov V, Xia Z, Baertsch R, Neeman E, Gao AC, Thomas GV, Howard L, Hoedt MD, Stuart J, Goldstein T, Chi K, Gleave ME, Graff JN, Beer TM, Drake JM, Evans CP, Aggarwal R, Foye A, Feng FY, Small EJ, Aronson WJ, Freedland SJ, Witte ON, Huang J, Alumkal JJ, Reiter RE, Rettig MB
    2019 Dec;22(4):531-538. doi: 10.1038/s41391-019-0134-5. Epub 2019 Feb 25.
  • Prostate Cancer Genomic-risk Differences Between African-American and White Men Across Gleason Scores European urology
    Mahal BA, Alshalalfa M, Spratt DE, Davicioni E, Zhao SG, Feng FY, Rebbeck TR, Nguyen PL, Huang FW
    2019 Jun;75(6):1038-1040. doi: 10.1016/j.eururo.2019.01.010. Epub 2019 Jan 22.
  • Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas Clinical cancer research : an official journal of the American Association for Cancer Research
    Zhao SG, Chen WS, Das R, Chang SL, Tomlins SA, Chou J, Quigley DA, Dang HX, Barnard TJ, Mahal BA, Gibb EA, Liu Y, Davicioni E, Duska LR, Posadas EM, Jolly S, Spratt DE, Nguyen PL, Maher CA, Small EJ, Feng FY
    2019 Apr 15;25(8):2450-2457. doi: 10.1158/1078-0432.CCR-18-3121. Epub 2018 Dec 20.
  • PARP-1 regulates DNA repair factor availability EMBO molecular medicine
    Schiewer MJ, Mandigo AC, Gordon N, Huang F, Gaur S, Leeuw Rd, Zhao SG, Evans J, Han S, Parsons T, Birbe R, McCue P, McNair C, Chand SN, Cendon-Florez Y, Gallagher P, McCann JJ, Neupane NP, Shafi AA, Dylgjeri E, Brand LJ, Visakorpi T, Raj GV, Lallas CD, Trabulsi EJ, Gomella LG, Dicker AP, Kelly WK, Leiby BE, Knudsen B, Feng FY, Knudsen KE
    2018 Dec;10(12):e8816. doi: 10.15252/emmm.201708816.
  • The Immune Landscape of Prostate Cancer and Nomination of PD-L2 as a Potential Therapeutic Target Journal of the National Cancer Institute
    Zhao SG, Lehrer J, Chang SL, Das R, Erho N, Liu Y, Sjöström M, Den RB, Freedland SJ, Klein EA, Karnes RJ, Schaeffer EM, Xu M, Speers C, Nguyen PL, Ross AE, Chan JM, Cooperberg MR, Carroll PR, Davicioni E, Fong L, Spratt DE, Feng FY
    2019 Mar 1;111(3):301-310. doi: 10.1093/jnci/djy141.
  • Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer Cell
    Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY
    2018 Jul 26;174(3):758-769.e9. doi: 10.1016/j.cell.2018.06.039. Epub 2018 Jul 19.
    • More

      PMID:30033370 | PMC:PMC6425931 | DOI:10.1016/j.cell.2018.06.039


      View details for PubMedID 30033370
  • The Diverse Genomic Landscape of Clinically Low-risk Prostate Cancer European urology
    Cooperberg MR, Erho N, Chan JM, Feng FY, Fishbane N, Zhao SG, Simko JP, Cowan JE, Lehrer J, Alshalalfa M, Kolisnik T, Chelliserry J, Margrave J, Aranes M, Plessis Md, Buerki C, Tenggara I, Davicioni E, Carroll PR
    2018 Oct;74(4):444-452. doi: 10.1016/j.eururo.2018.05.014. Epub 2018 May 28.
    • More

      PMID:29853306 | PMC:PMC6586429 | DOI:10.1016/j.eururo.2018.05.014


      View details for PubMedID 29853306
  • Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy Clinical cancer research : an official journal of the American Association for Cancer Research
    Karnes RJ, Sharma V, Choeurng V, Ashab HA, Erho N, Alshalalfa M, Trock B, Ross A, Yousefi K, Tsai H, Zhao SG, Tosoian JJ, Haddad Z, Takhar M, Chang SL, Spratt DE, Abdollah F, Jenkins RB, Klein EA, Nguyen PL, Dicker AP, Den RB, Davicioni E, Feng FY, Lotan TL, Schaeffer EM
    2018 Aug 15;24(16):3908-3916. doi: 10.1158/1078-0432.CCR-17-2745. Epub 2018 May 14.
    • More

      PMID:29760221 | PMC:PMC6512950 | DOI:10.1158/1078-0432.CCR-17-2745


      View details for PubMedID 29760221
  • Development and Validation of a Novel Integrated Clinical-Genomic Risk Group Classification for Localized Prostate Cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Spratt DE, Zhang J, Santiago-Jiménez M, Dess RT, Davis JW, Den RB, Dicker AP, Kane CJ, Pollack A, Stoyanova R, Abdollah F, Ross AE, Cole A, Uchio E, Randall JM, Nguyen H, Zhao SG, Mehra R, Glass AG, Lam LC, Chelliserry J, Plessis Md, Choeurng V, Aranes M, Kolisnik T, Margrave J, Alter J, Jordan J, Buerki C, Yousefi K, Haddad Z, Davicioni E, Trabulsi EJ, Loeb S, Tewari A, Carroll PR, Weinmann S, Schaeffer EM, Klein EA, Karnes RJ, Feng FY, Nguyen PL
    2018 Feb 20;36(6):581-590. doi: 10.1200/JCO.2017.74.2940. Epub 2017 Nov 29.
  • Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer NPJ breast cancer
    Speers C, Zhao SG, Chandler B, Liu M, Wilder-Romans K, Olsen E, Nyati S, Ritter C, Alluri PG, Kothari V, Hayes DF, Lawrence TS, Spratt DE, Wahl DR, Pierce LJ, Feng FY
    2017 Aug 18;3:29. doi: 10.1038/s41523-017-0038-2. eCollection 2017.
  • Individual Patient Data Analysis of Randomized Clinical Trials: Impact of Black Race on Castration-resistant Prostate Cancer Outcomes European urology focus
    Spratt DE, Chen Y, Mahal BA, Osborne JR, Zhao SG, Morgan TM, Palapattu G, Feng FY, Nguyen PL
    2016 Dec;2(5):532-539. doi: 10.1016/j.euf.2016.03.010. Epub 2016 Apr 1.
  • Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing Proceedings of the National Academy of Sciences of the United States of America
    Fei T, Chen Y, Xiao T, Li W, Cato L, Zhang P, Cotter MB, Bowden M, Lis RT, Zhao SG, Wu Q, Feng FY, Loda M, He HH, Liu XS, Brown M
    2017 Jun 27;114(26):E5207-E5215. doi: 10.1073/pnas.1617467114. Epub 2017 Jun 13.
  • Associations of Luminal and Basal Subtyping of Prostate Cancer With Prognosis and Response to Androgen Deprivation Therapy JAMA oncology
    Zhao SG, Chang SL, Erho N, Yu M, Lehrer J, Alshalalfa M, Speers C, Cooperberg MR, Kim W, Ryan CJ, Den RB, Freedland SJ, Posadas E, Sandler H, Klein EA, Black P, Seiler R, Tomlins SA, Chinnaiyan AM, Jenkins RB, Davicioni E, Ross AE, Schaeffer EM, Nguyen PL, Carroll PR, Karnes RJ, Spratt DE, Feng FY
    2017 Dec 1;3(12):1663-1672. doi: 10.1001/jamaoncol.2017.0751.
    • More

      PMID:28494073 | PMC:PMC5824281 | DOI:10.1001/jamaoncol.2017.0751


      View details for PubMedID 28494073
  • Individual Patient-Level Meta-Analysis of the Performance of the Decipher Genomic Classifier in High-Risk Men After Prostatectomy to Predict Development of Metastatic Disease Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Spratt DE, Yousefi K, Deheshi S, Ross AE, Den RB, Schaeffer EM, Trock BJ, Zhang J, Glass AG, Dicker AP, Abdollah F, Zhao SG, Lam LC, Plessis Md, Choeurng V, Haddad Z, Buerki C, Davicioni E, Weinmann S, Freedland SJ, Klein EA, Karnes RJ, Feng FY
    2017 Jun 20;35(18):1991-1998. doi: 10.1200/JCO.2016.70.2811. Epub 2017 Mar 30.
  • Anatomical patterns of recurrence following biochemical relapse after post-prostatectomy salvage radiation therapy: a multi-institutional study BJU international
    Jackson WC, Desai NB, Abugharib AE, Tumati V, Dess RT, Lee JY, Zhao SG, Soliman M, Folkert M, Laine A, Hannan R, Zumsteg ZS, Sandler H, Hamstra DA, Montgomery JS, Miller DC, Kozminski MA, Hollenbeck BK, Hearn JW, Palapattu G, Tomlins SA, Mehra R, Morgan TM, Feng FY, Spratt DE
    2017 Sep;120(3):351-357. doi: 10.1111/bju.13792. Epub 2017 Feb 26.
  • MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2 Cancer research
    Das R, Gregory PA, Fernandes RC, Denis I, Wang Q, Townley SL, Zhao SG, Hanson AR, Pickering MA, Armstrong HK, Lokman NA, Ebrahimie E, Davicioni E, Jenkins RB, Karnes RJ, Ross AE, Den RB, Klein EA, Chi KN, Ramshaw HS, Williams ED, Zoubeidi A, Goodall GJ, Feng FY, Butler LM, Tilley WD, Selth LA
    2017 Feb 15;77(4):1021-1034. doi: 10.1158/0008-5472.CAN-16-2529. Epub 2016 Dec 23.
  • RB Loss Promotes Prostate Cancer Metastasis Cancer research
    Thangavel C, Boopathi E, Liu Y, Haber A, Ertel A, Bhardwaj A, Addya S, Williams N, Ciment SJ, Cotzia P, Dean JL, Snook A, McNair C, Price M, Hernandez JR, Zhao SG, Birbe R, McCarthy JB, Turley EA, Pienta KJ, Feng FY, Dicker AP, Knudsen KE, Den RB
    2017 Feb 15;77(4):982-995. doi: 10.1158/0008-5472.CAN-16-1589. Epub 2016 Dec 6.
    • More

      PMID:27923835 | PMC:PMC5700768 | DOI:10.1158/0008-5472.CAN-16-1589


      View details for PubMedID 27923835
  • Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis Cancer research
    Wahl DR, Dresser J, Wilder-Romans K, Parsels JD, Zhao SG, Davis M, Zhao L, Kachman M, Wernisch S, Burant CF, Morgan MA, Feng FY, Speers C, Lyssiotis CA, Lawrence TS
    2017 Feb 15;77(4):960-970. doi: 10.1158/0008-5472.CAN-16-2008. Epub 2016 Dec 6.
    • More

      PMID:27923831 | PMC:PMC5726266 | DOI:10.1158/0008-5472.CAN-16-2008


      View details for PubMedID 27923831
  • Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis Prostate cancer and prostatic diseases
    Benzon B, Zhao SG, Haffner MC, Takhar M, Erho N, Yousefi K, Hurley P, Bishop JL, Tosoian J, Ghabili K, Alshalalfa M, Glavaris S, Simons BW, Tran P, Davicioni E, Karnes RJ, Boudadi K, Antonarakis ES, Schaeffer EM, Drake CG, Feng F, Ross AE
    2017 Mar;20(1):28-35. doi: 10.1038/pcan.2016.49. Epub 2016 Nov 1.
  • Development and validation of a 24-gene predictor of response to postoperative radiotherapy in prostate cancer: a matched, retrospective analysis The Lancet. Oncology
    Zhao SG, Chang SL, Spratt DE, Erho N, Yu M, Ashab HA, Alshalalfa M, Speers C, Tomlins SA, Davicioni E, Dicker AP, Carroll PR, Cooperberg MR, Freedland SJ, Karnes RJ, Ross AE, Schaeffer EM, Den RB, Nguyen PL, Feng FY
    2016 Nov;17(11):1612-1620. doi: 10.1016/S1470-2045(16)30491-0. Epub 2016 Oct 12.
  • Cell cycle-coupled expansion of AR activity promotes cancer progression Oncogene
    McNair C, Urbanucci A, Comstock ES, Augello MA, Goodwin JF, Launchbury R, Zhao SG, Schiewer MJ, Ertel A, Karnes J, Davicioni E, Wang L, Wang Q, Mills IG, Feng FY, Li W, Carroll JS, Knudsen KE
    2017 Mar 23;36(12):1655-1668. doi: 10.1038/onc.2016.334. Epub 2016 Sep 26.
  • The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression Nature communications
    Niknafs YS, Han S, Ma T, Speers C, Zhang C, Wilder-Romans K, Iyer MK, Pitchiaya S, Malik R, Hosono Y, Prensner JR, Poliakov A, Singhal U, Xiao L, Kregel S, Siebenaler RF, Zhao SG, Uhl M, Gawronski A, Hayes DF, Pierce LJ, Cao X, Collins C, Backofen R, Sahinalp CS, Rae JM, Chinnaiyan AM, Feng FY
    2016 Sep 26;7:12791. doi: 10.1038/ncomms12791.
  • Very Early Salvage Radiotherapy Improves Distant Metastasis-Free Survival The Journal of urology
    Abugharib A, Jackson WC, Tumati V, Dess RT, Lee JY, Zhao SG, Soliman M, Zumsteg ZS, Mehra R, Feng FY, Morgan TM, Desai N, Spratt DE
    2017 Mar;197(3 Pt 1):662-668. doi: 10.1016/j.juro.2016.08.106. Epub 2016 Sep 7.
  • Multi-institutional Analysis Shows that Low PCAT-14 Expression Associates with Poor Outcomes in Prostate Cancer European urology
    White NM, Zhao SG, Zhang J, Rozycki EB, Dang HX, McFadden SD, Eteleeb AM, Alshalalfa M, Vergara IA, Erho N, Arbeit JM, Karnes RJ, Den RB, Davicioni E, Maher CA
    2017 Feb;71(2):257-266. doi: 10.1016/j.eururo.2016.07.012. Epub 2016 Jul 22.
  • Maternal Embryonic Leucine Zipper Kinase (MELK) as a Novel Mediator and Biomarker of Radioresistance in Human Breast Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Speers C, Zhao SG, Kothari V, Santola A, Liu M, Wilder-Romans K, Evans J, Batra N, Bartelink H, Hayes DF, Lawrence TS, Brown PH, Pierce LJ, Feng FY
    2016 Dec 1;22(23):5864-5875. doi: 10.1158/1078-0432.CCR-15-2711. Epub 2016 May 25.
    • More

      PMID:27225691 | PMC:PMC8820108 | DOI:10.1158/1078-0432.CCR-15-2711


      View details for PubMedID 27225691
  • Independent validation of the prognostic capacity of the ISUP prostate cancer grade grouping system for radiation treated patients with long-term follow-up Prostate cancer and prostatic diseases
    Spratt DE, Jackson WC, Abugharib A, Tomlins SA, Dess RT, Soni PD, Lee JY, Zhao SG, Cole AI, Zumsteg ZS, Sandler H, Hamstra D, Hearn JW, Palapattu G, Mehra R, Morgan TM, Feng FY
    2016 Sep;19(3):292-7. doi: 10.1038/pcan.2016.18. Epub 2016 May 24.
  • Independent surgical validation of the new prostate cancer grade-grouping system BJU international
    Spratt DE, Cole AI, Palapattu GS, Weizer AZ, Jackson WC, Montgomery JS, Dess RT, Zhao SG, Lee JY, Wu A, Kunju LP, Talmich E, Miller DC, Hollenbeck BK, Tomlins SA, Feng FY, Mehra R, Morgan TM
    2016 Nov;118(5):763-769. doi: 10.1111/bju.13488. Epub 2016 Apr 19.
  • Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer JAMA oncology
    Evans JR, Zhao SG, Chang SL, Tomlins SA, Erho N, Sboner A, Schiewer MJ, Spratt DE, Kothari V, Klein EA, Den RB, Dicker AP, Karnes RJ, Yu X, Nguyen PL, Rubin MA, Bono Jd, Knudsen KE, Davicioni E, Feng FY
    2016 Apr;2(4):471-80. doi: 10.1001/jamaoncol.2015.4955.
    • More

      PMID:26746117 | PMC:PMC5469505 | DOI:10.1001/jamaoncol.2015.4955


      View details for PubMedID 26746117
  • The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Zhao SG, Evans JR, Kothari V, Sun G, Larm A, Mondine V, Schaeffer EM, Ross AE, Klein EA, Den RB, Dicker AP, Karnes RJ, Erho N, Nguyen PL, Davicioni E, Feng FY
    2016 Apr 1;22(7):1777-86. doi: 10.1158/1078-0432.CCR-15-1250. Epub 2015 Dec 2.
  • Maintaining physical activity during head and neck cancer treatment: Results of a pilot controlled trial Head & neck
    Zhao SG, Alexander NB, Djuric Z, Zhou J, Tao Y, Schipper M, Feng FY, Eisbruch A, Worden FP, Strath SJ, Jolly S
    2016 Apr;38 Suppl 1(Suppl 1):E1086-96. doi: 10.1002/hed.24162. Epub 2015 Oct 7.
  • Patient-reported quality of life after stereotactic body radiotherapy (SBRT), intensity modulated radiotherapy (IMRT), and brachytherapy Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
    Evans JR, Zhao S, Daignault S, Sanda MG, Michalski J, Sandler HM, Kuban DA, Ciezki J, Kaplan ID, Zietman AL, Hembroff L, Feng FY, Suy S, Skolarus TA, McLaughlin PW, Wei JT, Dunn RL, Finkelstein SE, Mantz CA, Collins SP, Hamstra DA, Consortium PS
    2015 Aug;116(2):179-84. doi: 10.1016/j.radonc.2015.07.016. Epub 2015 Aug 11.
  • DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis Cancer cell
    Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE
    2015 Jul 13;28(1):97-113. doi: 10.1016/j.ccell.2015.06.004.
    • More

      PMID:26175416 | PMC:PMC4531387 | DOI:10.1016/j.ccell.2015.06.004


      View details for PubMedID 26175416
  • Endothelial CXCR7 regulates breast cancer metastasis Oncogene
    Stacer AC, Fenner J, Cavnar SP, Xiao A, Zhao S, Chang SL, Salomonnson A, Luker KE, Luker GD
    2016 Mar 31;35(13):1716-24. doi: 10.1038/onc.2015.236. Epub 2015 Jun 29.
  • High-throughput transcriptomic analysis nominates proteasomal genes as age-specific biomarkers and therapeutic targets in prostate cancer Prostate cancer and prostatic diseases
    Zhao SG, Jackson WC, Kothari V, Schipper MJ, Erho N, Evans JR, Speers C, Hamstra DA, Niknafs YS, Nguyen PL, Schaeffer EM, Ross AE, Den RB, Klein EA, Jenkins RB, Davicioni E, Feng FY
    2015 Sep;18(3):229-36. doi: 10.1038/pcan.2015.22. Epub 2015 May 19.
  • Development and validation of a novel platform-independent metastasis signature in human breast cancer PloS one
    Zhao SG, Shilkrut M, Speers C, Liu M, Wilder-Romans K, Lawrence TS, Pierce LJ, Feng FY
    2015 May 14;10(5):e0126631. doi: 10.1371/journal.pone.0126631. eCollection 2015.
    • More

      PMID:25974184 | PMC:PMC4431866 | DOI:10.1371/journal.pone.0126631


      View details for PubMedID 25974184
  • Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes European urology
    Tomlins SA, Alshalalfa M, Davicioni E, Erho N, Yousefi K, Zhao S, Haddad Z, Den RB, Dicker AP, Trock BJ, DeMarzo AM, Ross AE, Schaeffer EM, Klein EA, Magi-Galluzzi C, Karnes RJ, Jenkins RB, Feng FY
    2015 Oct;68(4):555-67. doi: 10.1016/j.eururo.2015.04.033. Epub 2015 May 8.
    • More

      PMID:25964175 | PMC:PMC4562381 | DOI:10.1016/j.eururo.2015.04.033


      View details for PubMedID 25964175
  • Development and Validation of a Novel Radiosensitivity Signature in Human Breast Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Speers C, Zhao S, Liu M, Bartelink H, Pierce LJ, Feng FY
    2015 Aug 15;21(16):3667-77. doi: 10.1158/1078-0432.CCR-14-2898. Epub 2015 Apr 22.
  • The landscape of long noncoding RNAs in the human transcriptome Nature genetics
    Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette TR, Prensner JR, Evans JR, Zhao S, Poliakov A, Cao X, Dhanasekaran SM, Wu Y, Robinson DR, Beer DG, Feng FY, Iyer HK, Chinnaiyan AM
    2015 Mar;47(3):199-208. doi: 10.1038/ng.3192. Epub 2015 Jan 19.
  • RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1 The Lancet. Oncology
    Prensner JR, Zhao S, Erho N, Schipper M, Iyer MK, Dhanasekaran SM, Magi-Galluzzi C, Mehra R, Sahu A, Siddiqui J, Davicioni E, Den RB, Dicker AP, Karnes RJ, Wei JT, Klein EA, Jenkins RB, Chinnaiyan AM, Feng FY
    2014 Dec;15(13):1469-1480. doi: 10.1016/S1470-2045(14)71113-1. Epub 2014 Nov 17.
    • More

      PMID:25456366 | PMC:PMC4559342 | DOI:10.1016/S1470-2045(14)71113-1


      View details for PubMedID 25456366
  • Etanercept plus topical corticosteroids as initial therapy for grade one acute graft-versus-host disease after allogeneic hematopoietic cell transplantation Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    Gatza E, Braun T, Levine JE, Ferrara LM, Zhao S, Wang T, Chang L, Harris A, Pawarode A, Kitko C, Magenau JM, Yanik GA, Couriel DR, Goldstein S, Connelly J, Reddy P, Paczesny S, Choi SW
    2014 Sep;20(9):1426-34. doi: 10.1016/j.bbmt.2014.05.023. Epub 2014 Jun 2.
    • More

      PMID:24892263 | PMC:PMC4145722 | DOI:10.1016/j.bbmt.2014.05.023


      View details for PubMedID 24892263
  • Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    Chang L, Frame D, Braun T, Gatza E, Hanauer DA, Zhao S, Magenau JM, Schultz K, Tokala H, Ferrara LM, Levine JE, Reddy P, Paczesny S, Choi SW
    2014 Sep;20(9):1407-17. doi: 10.1016/j.bbmt.2014.05.022. Epub 2014 Jun 2.
    • More

      PMID:24892262 | PMC:PMC4142041 | DOI:10.1016/j.bbmt.2014.05.022


      View details for PubMedID 24892262
  • A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer<sup>1,2</sup> Translational oncology
    Zhao S, Chang SL, Linderman JJ, Feng FY, Luker GD
    2014 May 13;7(3):429-38. doi: 10.1016/j.tranon.2014.04.001. Online ahead of print.
    • More

      PMID:24836649 | PMC:PMC4145355 | DOI:10.1016/j.tranon.2014.04.001


      View details for PubMedID 24836649
  • Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes Diabetologia
    Sims-Robinson C, Zhao S, Hur J, Feldman EL
    2012 Aug;55(8):2276-84. doi: 10.1007/s00125-012-2573-6. Epub 2012 May 14.
  • Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Pediatric Nephrology Consortium (MWPNC) study The Journal of pediatrics
    Kerlin BA, Blatt NB, Fuh B, Zhao S, Lehman A, Blanchong C, Mahan JD, Smoyer WE
    2009 Jul;155(1):105-10, 110.e1. doi: 10.1016/j.jpeds.2009.01.070. Epub 2009 Apr 24.
    • More

      PMID:19394032 | PMC:PMC3685482 | DOI:10.1016/j.jpeds.2009.01.070


      View details for PubMedID 19394032
  • Significance of hemolysis on extracorporeal life support after cardiac surgery in children Pediatric nephrology (Berlin, Germany)
    Gbadegesin R, Zhao S, Charpie J, Brophy PD, Smoyer WE, Lin J
    2009 Mar;24(3):589-95. doi: 10.1007/s00467-008-1047-z. Epub 2008 Nov 12.

Contact Information

Shuang (George) Zhao, MD


Email