Shuang (George) Zhao

Shuang (George) Zhao, MD

Assistant Professor

Department of Human Oncology

I am an assistant professor in the Department of Human Oncology. I completed my bachelor’s and master’s degrees in Computer Science & Engineering with a focus on Intelligent Systems at the University of Michigan. I then completed my MD at the University of Michigan Medical School. After a transitional year internship at Beaumont Hospital – Dearborn, I returned to the University of Michigan for residency training in radiation oncology. Under the American Board of Radiology’s Holman Pathway, I led multiple cancer genomics and biomarker studies under the mentorship of Dr. Felix Feng. As a physician-scientist, my clinical focus is on the treatment of patients with GU malignancies. My independent translational research laboratory focuses on using advances in sequencing and computational techniques to develop biomarkers of treatment response and resistance, primarily in prostate cancer. I co-direct the UWCCC Circulating Biomarker Core with Dr. Josh Lang, where we work on translating liquid biopsy technology into the clinic.


Residency, University of Michigan, Radiation Oncology (2020)

MD, University of Michigan, Medicine (2015)

MSE, University of Michigan, Computer Science and Engineering (2010)

BSE, University of Michigan, Computer Science and Engineering (2009)

Academic Appointments

Assistant Professor, Human Oncology (2020)

Co-director, University of Wisconsin Carbone Cancer Center Circulating Biomarker Core (2020)

Selected Honors and Awards

Roentgen Resident/Fellow Research Award (2020)

Radiation Research Society Scholar-in-Training Travel Award (2018)

MRS Resident Conference & Research Forum Radiation Oncology Abstract Award (2017)

ASTRO Resident Clinical/Basic Science Research Award in Biology (2015)

Dean’s Merit Scholarship, University of Michigan Medical School (2010-15)

William L. Everitt Award of Excellence, University of Michigan (2009)

James B. Angell Scholar, University of Michigan (2009)

Engineering Scholarship of Honor, University of Michigan (2005-09)

Pfizer Corporate Merit Scholarship, National Merit Scholarship Corporation (2005-09 )

Michigan Merit Award, State of Michigan (2005)

Regents Merit Scholarship, University of Michigan (2005)

Research Focus

GU malignancies

Biomarkers to personalize treatment in cancer 

In the Zhao Lab, we focus on developing novel clinical biomarkers that predict response and resistance to specific therapies across cancers. These biomarkers can be used to better select which patients derive a benefit from treatment, which patients do not and can be spared potential toxicity, as well as monitor for emergence of resistance. We seek to use advanced computational approaches and liquid biopsy technologies to better personalize the care of cancer patients.

Predictive biomarkers

Treatment decisions for cancer has historically been based on tissue of origin and other pathologic and clinical variables which give prognostic information on the overall level of aggressiveness of a tumor. Predictive biomarkers on the other hand are used to predict response to specific treatments, rather than overall prognosis. Such biomarkers have high clinical utility in deciding the optimal treatment approach for an individual patient. Our laboratory seeks to leverage advances in molecular medicine to identify new predictive biomarkers for standard and emerging cancer therapies.

predictive biomarkers graphs

  • SG Zhao*, SL Chang*, DE Spratt, N Erho, M Yu, HA Ashab, M Alshalalfa, C Speers, SA Tomlins, E Davicioni, AP Dicker, PR Carroll, MR Cooperberg, SJ Freedland, RJ Karnes, A Ross, EM Schaeffer, RB Den, PL Nguyen†, FY Feng†. The development and validation of a 24-gene predictor of response to post-operative radiation therapy in prostate cancer: a matched retrospective analysis. Lancet Oncology. PMID 27743920.
  • SG Zhao*, SL Chang*, N Erho, M Yu, J Lehrer, M Alshalalfa, C Speers, MR Cooperberg, W Kim, CJ Ryan, RB Den, SJ Freedland, E Posadas, H Sandler, EA Klein, P Black, R Seiler, SA Tomlins, AM Chinnaiyan MD, RB Jenkins, E Davicioni, AE Ross, EM Schaeffer, PL Nguyen, PR Carroll, RJ Karnes, DE Spratt†, FY Feng†. Associations of luminal and basal subtyping of prostate cancer with prognosis and response to androgen deprivation therapy. JAMA Oncology. PMID 28494073.
  • SG Zhao, M Yu, DE Spratt, SL Chang, FY Feng, MM Kim, CW Speers, BL Carlson, AC Mladek, TS Lawrence, JN Sarkaria, DR Wahl. Development and validation of xenograft-based platform-independent gene signatures that predict response to alkylating chemotherapy, radiation, and combination therapy in patients with glioblastoma. Neuro-Oncology. PMID 31121035.
  • NM White*, SG Zhao*, J Zhang, EB Rozycki, HX Dang, SD McFadden, AM Eteleeb, M Alshalalfa, IA Vergara, N Erho, JM Arbeitg, RJ Karnes, RB Den, E Davicioni, CA Maher. Multi-institutional analysis shows low PCAT-14 expression associates with poor outcome in prostate cancer. European Urology. PMID 27460352.
  • R Aggarwal*, NR Rydzewski*, L Zhang, A Foye, W Kim, KT Helzer, H Bakhtiar, SL Chang, MD Perry, M Gleave, RE Reiter, J Huang, CP Evans, JJ Alumkal, JM Lang, M Yu, DA Quigley, M Sjöström, EJ Small, FY Feng, SG Zhao. Prognosis associated with luminal and basal subtypes of metastatic prostate cancer. JAMA Oncology. PMID 34554200.

clinical next-generation sequencing

Integrated multi-omic next-generation sequencing (NGS) on clinical samples allows for a global view of the landscape of molecular alterations that drive cancer progression and treatment resistance. Our lab analyzes correlative sequencing data from clinical cohorts and trials to better understand the molecular underpinnings of the phenotypic behavior of tumors.

  • SG Zhao*, W Chen*, H Li*, A Foye, M Zhang, M Sjöstrjöm, R Aggarwal, D Playdle, A Liao, JJ Alumkal, R Das, J Chou, JT Hua, TJ Barnard, AM Bailey, E Chow, M Perry, HX Dang, R Yang, R Moussavi-Baygi, L Zhang, M Alshalalfa, SL Chang, KE Houlahan, YJ Shiah, TM Beer, G Thomas, KN Chi, M Gleave, A Zoubeidi, RE Reiter, MB Rettig, O Witte, Y Kim, L Fong, DE Spratt, TM Morgan, R Bose, FW Huang, H Li, L Chesner, T Shenoy, H Goodazi, IA Asangani, S Sandhu, JM Lang, PN Lara, N Mahajan, CP Evans, P Febbo, S Batzoglou, KE Knudsen, HH He, J Huang, W Zwart, JF Costello, J Luo, SA Tomlins, AW Wyatt, SM Dehm, A Ashworth, LA Gilbert, P Boutros, K Farh, AM Chinnaiyan†, CA Maher†, EJ Small†, DA Quigley†, FY Feng†. Hallmarks of epigenomic regulation in advanced prostate cancer. Nature Genetics. PMID 32661416.
  • DA Quigley*, HX Dang*, SG Zhao*, P Lloyd, R Aggarwal, JJ Alumkal, A Foye, V Kothari, M Perry, AM Bailey, D Playdle, TJ Barnard, L Zhang, J Zhang, JF Youngren, MP Cieslik, A Parolia, TM Beer, G Thomas, KN Chi, M Gleave, N Lack, A Zoubeidi, RE Reiter, M Rettig, O Witte, CJ Ryan, L Fong, W Kim, T Friedlander, J Chou, H Li, R Das, H Li, R Moussavi-Baygi, H Goodarzi, LA Gilbert, P Lara, CP Evans, TC Goldstein, JM Stuart, SA Tomlins, DE Spratt, RK Cheetham, DT Cheng, K Farh, JS Gehring, J Hakenberg, A Liao, P Febbo, J Shon, S Batzoglou, KE Knudsen, HH He, J Huang, AW Wyatt, SM Dehm, A Ashworth, AM Chinnaiyan†, CA Maher†, EJ Small†, FY Feng†. Genomic hallmarks and structural variation in metastatic prostate cancer. Cell. PMID 30033370.
  • SG Zhao*, WS Chen*, R Das, SL Chang, SA Tomlins, J Chou, DA Quigley, H Dang, T Barnard, BA Mahal, EA Gibb, Y Liu, E Davicioni, LR Duska, E Posadas, S Jolly, DE Spratt, PL Nguyen, CA Maher, EJ Small, FY Feng. Clinical and genomic implications of luminal and basal subtypes across carcinomas. Clinical Cancer Research. PMID 30573691.
  • E Feng*, NR Rydzewski*, M Zhang, A Lundberg, M Bootsma, KT Helzer, JM Lang, R Aggarwal, EJ Small, DA Quigley, M Sjöström, SG Zhao. Intrinsic molecular subtypes of metastatic castration-resistant prostate cancer. Clinical Cancer Research. In press. PMID 36260524.

Computational approaches

High-throughput sequencing techniques can generate an enormous amount of data. Machine-learning is the branch of computer science specifically focused on identifying important patterns in that are too complex for humans to independently explore. Our laboratory seeks to leverage machine learning and other advanced computational approaches to develop models for clinical and biological endpoints.

  • SG Zhao, J Lehrer, SL Chang, R Das, N Erho, Y Liu, M Sjöström, RB Den, SJ Freedland, EA Klein, RJ Karnes, EM Schaeffer, M Xu, C Speers, PL Nguyen, AE Ross, JM Chan, MR Cooperberg, PR Carroll, E Davicioni, L Fong, DE Spratt, FY Feng. The immune landscape of prostate cancer and nomination of PD-L2 as a potential therapeutic target. J Natl Cancer Inst. PMID 30321406.
  • SG Zhao*, JR Evans*, V Kothari, G Sun, A Larm, V Mondine, EM Schaeffer, AE Ross, EA Klein, RB Den, AP Dicker, RJ Karnes, N Erho, PL Nguyen, E Davicioni, FY Feng. The landscape of prognostic outlier genes in high-risk prostate cancer. Clinical Cancer Research. PMID 26631616.
  • JR Evans*, SG Zhao*, SL Chang, SA Tomlins, N Erho, A Sboner, MJ Schiewer, DE Spratt, V Kothari, EA Klein, RB Den, AP Dicker, RJ Karnes, X Yu, PL Nguyen, MA Rubin, J de Bono, KE Knudsen, E Davicioni, FY Feng. Patient-level DNA damage and repair pathway profiles and prognosis after prostatectomy for High-Risk Prostate Cancer. JAMA Oncology. PMID 26746117.
  • C Speers*, S Zhao*, H Bartelink, M Liu, LJ Pierce†, FY Feng†. Development and validation of a novel radiosensitivity signature in human breast cancer. Clinical Cancer Research. PMID 25904749.
  • NR Rydzewski, E Peterson, JM Lang, M Yu, SL Chang, M Sjöström, H Bakhtiar, G Song, KT Helzer, ML Bootsma, WS Chen, RM Shrestha, M Zhang, DA Quigley, R Aggarwal, EJ Small, DR Wahl, FY Feng†, SG Zhao†. Predicting Cancer Drug TARGETS – TreAtment Response Generalized Elastic-neT Signatures. NPJ Genom Med. PMID 34548481.
  • H Bakhtiar*, KT Helzer*, Y Park, Y Chen, NR Rydzewski, ML Bootsma, Y Shi, PM Harari, M Sharifi, M Sjöström, JM Lang, M Yu, SG Zhao. Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone. NPJ Genom Med. PMID 36253482.

Liquid Biomarkers

Obtaining tissue specimens from cancer patients for molecular analysis is logistically challenging to perform at scale, especially in metastatic cancer. In collaboration with the UWCCC Circulating Biomarker Core, we work on developing liquid biopsy approaches for circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and other non-invasively assays.

Figure showing data results.

  • JM Sperger*, H Emamekhoo*, RR McKay*, CN Stahlfeld, A Singh, XE Chen, L Kwak, CS Gilsdorf, SK Wolfe, XX Wei, R Silver, Z Zhang, MJ Morris, G Bubley, FY Feng, HI Scher, D Rathkopf, SM Dehm, TK Choueiri, S Halabi, AJ Armstrong, AW Wyatt, ME Taplin, SG Zhao, JM Lang. Prospective evaluation of clinical outcomes utilizing a multi-plex liquid biopsy targeting diverse resistance mechanisms in metastatic prostate cancer. J Clin Oncol. PMID 34197212.
  • M Bootsma*, RR McKay*, H Emamekhoo*, RM Bade, JL Schehr, MC Mannino, A Singh, SK Wolfe, ZD Schultz, J Sperger, W Xie, S Signoretti, CE Kyriakopoulos, D Kosoff, EJ Abel, KT Helzer, N Rydzewski, H Bakhtiar, Y Shi, G Blitzer, M Bassetti, J Floberg, M Yu, N Sethakorn, M Sharifi, PM Harari, TK Choueiri, JM Lang, SG Zhao. Longitudinal molecular profiling of circulating tumor cells in metastatic renal cell carcinoma. J Clin Oncol. PMID 35617646.
  • JR Prensner*, S Zhao*, N Erho, M Schipper, MK Iyer, SM Dhanasekaran, C Magi-Galluzzi, R Mehra, A Sahu, J Siddiqui, E Davicioni, RB Den, AP Dicker, RJ Karnes, JT Wei, EA Klein, RB Jenkins, AM Chinnaiyan, FY Feng. RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1. Lancet Oncology. PMID 25456366.
  • SG Zhao*, JM Sperger*, JL Schehr*, RR McKay, H Emamekhoo, A Singh, ZD Schultz, RM Bade, CN Stahlfeld, CS Gilsdorf, CI Hernandez, SK Wolfe, RD Mayberry, HM Krause, M Bootsma, KT Helzer, N Rydzewski, H Bakhtiar, Y Shi, G Blitzer, CE Kyriakopoulos, D Kosoff, XX Wei, J Floberg, N Sethakorn, M Sharifi, PM Harari, W Huang, H Beltran, TK Choueiri, HI Scher, DE Rathkopf, S Halabi, AJ Armstrong, DJ Beebe, M Yu, KE Sundling, ME Taplin, JM Lang. A clinical-grade liquid biomarker to detect neuroendocrine differentiation in prostate cancer. J Clin Invest. 2022 Nov 1;132(21). PMID 36317634.
  • M Sjöström*, SG Zhao*, S Levy*, M Zhang*, Y Ning, R Shrestha, A Lundberg, C Herberts, A Foye, R Aggarwal, JT Hua, H Li, A Bergamaschi, C Maurice-Dror, A Maheshwari, S Chen, SWS Ng, W Ye, J Petricca, M Fraser, L Chesner, MD Perry, T Moreno-Rodriguez, WS Chen, JJ Alumkal, J Chou, AK Morgans, TM Beer, GV Thomas, M Gleave, P Lloyd, T Phillips, E McCarthy, MC Haffner, A Zoubeidi, M Annala, RE Reiter, MB Rettig, O Witte, L Fong, R Bose, FW Huang, J Luo, A Bjartell, JM Lang, NP Mahajan, PN Lara, CP Evans, PT Tran, EM Posadas, C He, X Cui, J Huang, W Zwart, LA Gilbert, CA Maher, PC Boutros, KN Chi, A Ashworth, EJ Small, HH He, AW Wyatt, DA Quigley, FY Feng. The 5-hydroxymethylcytosine landscape of prostate cancer. Cancer Research. 2022 Nov 2;82(21):3888-3902. PMID 36251389.

*Co-first authorship, †Co-senior authorship


  • Prostate Cancer Foundation Young Investigator Award (Principal Investigator)
  • DoD Prostate Cancer Research Program Translational Science Award (Partnering Principal Investigator)
  • DoD Prostate Cancer Research Program Physician Research Award (Principal Investigator)
  • DoD Prostate Cancer Research Program Idea Award (Principal Investigator)
  • NIH DP2 Director’s New Innovator Award (Principal Investigator)
  • NCCN Young Investigator Award (Principal Investigator)
  • A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer The Journal of clinical investigation
    Zhao SG, Sperger JM, Schehr JL, McKay RR, Emamekhoo H, Singh A, Schultz ZD, Bade RM, Stahlfeld CN, Gilsdorf CS, Hernandez CI, Wolfe SK, Mayberry RD, Krause HM, Bootsma M, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Kyriakopoulos CE, Kosoff D, Wei XX, Floberg J, Sethakorn N, Sharifi M, Harari PM, Huang W, Beltran H, Choueiri TK, Scher HI, Rathkopf DE, Halabi S, Armstrong AJ, Beebe DJ, Yu M, Sundling KE, Taplin M, Lang JM
    2022 Nov 1;132(21):e161858. doi: 10.1172/JCI161858.
  • Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Feng E, Rydzewski NR, Zhang M, Lundberg A, Bootsma M, Helzer KT, Lang JM, Aggarwal R, Small EJ, Quigley DA, Sjöström M, Zhao SG
    2022 Oct 19:CCR-22-2567. doi: 10.1158/1078-0432.CCR-22-2567. Online ahead of print.
  • Identification of phenocopies improves prediction of targeted therapy response over DNA mutations alone NPJ genomic medicine
    Bakhtiar H, Helzer KT, Park Y, Chen Y, Rydzewski NR, Bootsma ML, Shi Y, Harari PM, Sharifi M, Sjöström M, Lang JM, Yu M, Zhao SG
    2022 Oct 17;7(1):58. doi: 10.1038/s41525-022-00328-7.
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      PMID:36253482 | PMC:PMC9576758 | DOI:10.1038/s41525-022-00328-7

      View details for PubMedID 36253482
  • The 5-Hydroxymethylcytosine Landscape of Prostate Cancer Cancer research
    Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng WS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui X, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY
    2022 Nov 2;82(21):3888-3902. doi: 10.1158/0008-5472.CAN-22-1123.
  • Radiomic Modeling of Bone Density and Rib Fracture Risk After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer Advances in radiation oncology
    Rydzewski NR, Yadav P, Musunuru HB, Condit KM, Francis D, Zhao SG, Baschnagel AM
    2021 Dec 29;7(3):100884. doi: 10.1016/j.adro.2021.100884. eCollection 2022 May-Jun.
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      PMID:35647405 | PMC:PMC9133372 | DOI:10.1016/j.adro.2021.100884

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  • Longitudinal Molecular Profiling of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Bootsma M, McKay RR, Emamekhoo H, Bade RM, Schehr JL, Mannino MC, Singh A, Wolfe SK, Schultz ZD, Sperger J, Xie W, Signoretti S, Kyriakopoulos CE, Kosoff D, Abel EJ, Helzer KT, Rydzewski N, Bakhtiar H, Shi Y, Blitzer G, Bassetti M, Floberg J, Yu M, Sethakorn N, Sharifi M, Harari PM, Choueiri TK, Lang JM, Zhao SG
    2022 Nov 1;40(31):3633-3641. doi: 10.1200/JCO.22.00219. Epub 2022 May 26.
  • A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer Molecular cancer
    Fletcher CE, Deng L, Orafidiya F, Yuan W, Lorentzen GS, Cyran OW, Varela-Carver A, Constantin TA, Leach DA, Dobbs FM, Figueiredo I, Gurel B, Parkes E, Bogdan D, Pereira RR, Zhao SG, Neeb A, Issa F, Hester J, Kudo H, Liu Y, Philippou Y, Bristow R, Knudsen K, Bryant RJ, Feng FY, Reed SH, Mills IG, Bono Jd, Bevan CL
    2022 Mar 22;21(1):82. doi: 10.1186/s12943-022-01540-w.
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      PMID:35317841 | PMC:PMC8939142 | DOI:10.1186/s12943-022-01540-w

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  • SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples Clinical epigenetics
    Rodems TS, Juang DS, Stahlfeld CN, Gilsdorf CS, Krueger EG, Heninger E, Zhao SG, Sperger JM, Beebe DJ, Haffner MC, Lang JM
    2022 Mar 10;14(1):37. doi: 10.1186/s13148-022-01252-4.
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      PMID:35272673 | PMC:PMC8908705 | DOI:10.1186/s13148-022-01252-4

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  • Reply to M. K. Bos et al Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Sperger JM, Feng FY, Armstrong AJ, Zhao SG, Lang JM
    2022 Feb 10;40(5):520-522. doi: 10.1200/JCO.21.02238. Epub 2021 Dec 8.
  • Prostate cancer research in the 21st century; report from the 2021 Coffey-Holden prostate cancer academy meeting The Prostate
    Miyahira AK, Zarif JC, Coombs CC, Flavell RR, Russo JW, Zaidi S, Zhao D, Zhao SG, Pienta KJ, Soule HR
    2022 Feb;82(2):169-181. doi: 10.1002/pros.24262. Epub 2021 Nov 3.
  • Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer JAMA oncology
    Aggarwal R, Rydzewski NR, Zhang L, Foye A, Kim W, Helzer KT, Bakhtiar H, Chang SL, Perry MD, Gleave M, Reiter RE, Huang J, Evans CP, Alumkal JJ, Lang JM, Yu M, Quigley DA, Sjöström M, Small EJ, Feng FY, Zhao SG
    2021 Nov 1;7(11):1644-1652. doi: 10.1001/jamaoncol.2021.3987.
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      PMID:34554200 | PMC:PMC8461554 | DOI:10.1001/jamaoncol.2021.3987

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  • Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE) Cancer genetics
    Swami N, Hwang WL, Guo JA, Hoffman H, Abramowitz MC, Elbakouny Z, Beltran H, Chipidza F, Choueiri T, Pra AD, Huang F, Kaochar S, Kantoff P, Kim DW, Kishan AU, Kobetz E, Marinac C, Mucci LA, Muralidhar V, Pollack A, Sanford NN, Schaeffer EM, Spratt DE, Zhao SG, Rebbeck TR, Nguyen PL, Feng FY, Mahal BA, Alshalalfa M
    2021 Nov;258-259:61-68. doi: 10.1016/j.cancergen.2021.08.004. Epub 2021 Aug 28.
  • Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures NPJ genomic medicine
    Rydzewski NR, Peterson E, Lang JM, Yu M, Chang SL, Sjöström M, Bakhtiar H, Song G, Helzer KT, Bootsma ML, Chen WS, Shrestha RM, Zhang M, Quigley DA, Aggarwal R, Small EJ, Wahl DR, Feng FY, Zhao SG
    2021 Sep 21;6(1):76. doi: 10.1038/s41525-021-00239-z.
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      PMID:34548481 | PMC:PMC8455625 | DOI:10.1038/s41525-021-00239-z

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  • ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts Molecular cancer therapeutics
    Baschnagel AM, Elnaggar JH, VanBeek HJ, Kromke AC, Skiba JH, Kaushik S, Abel L, Clark PA, Longhurst CA, Nickel KP, Leal TA, Zhao SG, Kimple RJ
    2021 Nov;20(11):2129-2139. doi: 10.1158/1535-7163.MCT-21-0305. Epub 2021 Aug 19.
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      PMID:34413128 | PMC:PMC8571002 | DOI:10.1158/1535-7163.MCT-21-0305

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  • Prospective Evaluation of Clinical Outcomes Using a Multiplex Liquid Biopsy Targeting Diverse Resistance Mechanisms in Metastatic Prostate Cancer Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    Sperger JM, Emamekhoo H, McKay RR, Stahlfeld CN, Singh A, Chen XE, Kwak L, Gilsdorf CS, Wolfe SK, Wei XX, Silver R, Zhang Z, Morris MJ, Bubley G, Feng FY, Scher HI, Rathkopf D, Dehm SM, Choueiri TK, Halabi S, Armstrong AJ, Wyatt AW, Taplin M, Zhao SG, Lang JM
    2021 Sep 10;39(26):2926-2937. doi: 10.1200/JCO.21.00169. Epub 2021 Jul 1.
  • Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance Clinical cancer research : an official journal of the American Association for Cancer Research
    McKay RR, Kwak L, Crowdis JP, Sperger JM, Zhao SG, Xie W, Werner L, Lis RT, Zhang Z, Wei XX, Lang JM, Van Allen M, Bhatt RS, Yu EY, Nelson PS, Bubley GJ, Montgomery RB, Taplin M
    2021 Jul 1;27(13):3610-3619. doi: 10.1158/1078-0432.CCR-20-4616. Epub 2021 Apr 13.
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      PMID:33849963 | PMC:PMC8254786 | DOI:10.1158/1078-0432.CCR-20-4616

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  • Prostate-specific Membrane Antigen and Fluciclovine Transporter Genes are Associated with Variable Clinical Features and Molecular Subtypes of Primary Prostate Cancer European urology
    Chu CE, Alshalalfa M, Sjöström M, Zhao SG, Liu Y, Chou J, Herlemann A, Mahal B, Kishan AU, Spratt DE, Cooperberg M, Small E, Wong A, Porten S, Hope TA, Ross AE, Davicioni E, Nguyen P, Karnes RJ, Carroll PR, Schaeffer E, Feng FY
    2021 Jun;79(6):717-721. doi: 10.1016/j.eururo.2021.03.017. Epub 2021 Apr 8.
  • Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer European urology
    Kumaraswamy A, Leng RW, Westbrook TC, Yates JA, Zhao SG, Evans CP, Feng FY, Morgan TM, Alumkal JJ
    2021 Jul;80(1):71-81. doi: 10.1016/j.eururo.2021.03.005. Epub 2021 Mar 27.
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      PMID:33785255 | PMC:PMC8547521 | DOI:10.1016/j.eururo.2021.03.005

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  • Validation of a 22-Gene Genomic Classifier in Patients With Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial JAMA oncology
    Feng FY, Huang H, Spratt DE, Zhao SG, Sandler HM, Simko JP, Davicioni E, Nguyen PL, Pollack A, Efstathiou JA, Dicker AP, Todorovic T, Margrave J, Liu YS, Dabbas B, Thompson JS, Das R, Dignam JJ, Sweeney C, Attard G, Bahary J, Lukka HR, Hall WA, Pisansky TM, Shah AB, Pugh SL, Shipley WU, Tran PT
    2021 Apr 1;7(4):544-552. doi: 10.1001/jamaoncol.2020.7671.
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      PMID:33570548 | PMC:PMC7879385 | DOI:10.1001/jamaoncol.2020.7671

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  • Novel Transcriptomic Interactions Between Immune Content and Genomic Classifier Predict Lethal Outcomes in High-grade Prostate Cancer European urology
    Yamoah K, Awasthi S, Mahal BA, Zhao SG, Grass GD, Berglund A, Abraham-Miranda J, Gerke T, Rounbehler RJ, Davicioni E, Liu Y, Park J, Cleveland JL, Pow-Sang JM, Fernandez D, Torres-Roca J, Karnes RJ, Schaeffer E, Freedland SJ, Spratt DE, Den RB, Rebbeck TR, Feng F
    2022 Apr;81(4):325-330. doi: 10.1016/j.eururo.2020.11.038. Epub 2020 Dec 7.
  • A Systematic Review of the Evidence for the Decipher Genomic Classifier in Prostate Cancer European urology
    Jairath NK, Pra AD, Vince R, Dess RT, Jackson WC, Tosoian JJ, McBride SM, Zhao SG, Berlin A, Mahal BA, Kishan AU, Den RB, Freedland SJ, Salami SS, Kaffenberger SD, Pollack A, Tran P, Mehra R, Morgan TM, Weiner AB, Mohamad O, Carroll PR, Cooperberg MR, Karnes RJ, Nguyen PL, Michalski JM, Tward JD, Feng FY, Schaeffer EM, Spratt DE
    2021 Mar;79(3):374-383. doi: 10.1016/j.eururo.2020.11.021. Epub 2020 Dec 5.
  • SV-HotSpot: detection and visualization of hotspots targeted by structural variants associated with gene expression Scientific reports
    Eteleeb AM, Quigley DA, Zhao SG, Pham D, Yang R, Dehm SM, Luo J, Feng FY, Dang HX, Maher CA
    2020 Sep 28;10(1):15890. doi: 10.1038/s41598-020-71168-7.
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      PMID:32985524 | PMC:PMC7522247 | DOI:10.1038/s41598-020-71168-7

      View details for PubMedID 32985524
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    2016 Sep;19(3):292-7. doi: 10.1038/pcan.2016.18. Epub 2016 May 24.
  • Independent surgical validation of the new prostate cancer grade-grouping system BJU international
    Spratt DE, Cole AI, Palapattu GS, Weizer AZ, Jackson WC, Montgomery JS, Dess RT, Zhao SG, Lee JY, Wu A, Kunju LP, Talmich E, Miller DC, Hollenbeck BK, Tomlins SA, Feng FY, Mehra R, Morgan TM
    2016 Nov;118(5):763-769. doi: 10.1111/bju.13488. Epub 2016 Apr 19.
  • Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer JAMA oncology
    Evans JR, Zhao SG, Chang SL, Tomlins SA, Erho N, Sboner A, Schiewer MJ, Spratt DE, Kothari V, Klein EA, Den RB, Dicker AP, Karnes RJ, Yu X, Nguyen PL, Rubin MA, Bono Jd, Knudsen KE, Davicioni E, Feng FY
    2016 Apr;2(4):471-80. doi: 10.1001/jamaoncol.2015.4955.
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      PMID:26746117 | PMC:PMC5469505 | DOI:10.1001/jamaoncol.2015.4955

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  • The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Zhao SG, Evans JR, Kothari V, Sun G, Larm A, Mondine V, Schaeffer EM, Ross AE, Klein EA, Den RB, Dicker AP, Karnes RJ, Erho N, Nguyen PL, Davicioni E, Feng FY
    2016 Apr 1;22(7):1777-86. doi: 10.1158/1078-0432.CCR-15-1250. Epub 2015 Dec 2.
  • Maintaining physical activity during head and neck cancer treatment: Results of a pilot controlled trial Head & neck
    Zhao SG, Alexander NB, Djuric Z, Zhou J, Tao Y, Schipper M, Feng FY, Eisbruch A, Worden FP, Strath SJ, Jolly S
    2016 Apr;38 Suppl 1(Suppl 1):E1086-96. doi: 10.1002/hed.24162. Epub 2015 Oct 7.
  • Patient-reported quality of life after stereotactic body radiotherapy (SBRT), intensity modulated radiotherapy (IMRT), and brachytherapy Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
    Evans JR, Zhao S, Daignault S, Sanda MG, Michalski J, Sandler HM, Kuban DA, Ciezki J, Kaplan ID, Zietman AL, Hembroff L, Feng FY, Suy S, Skolarus TA, McLaughlin PW, Wei JT, Dunn RL, Finkelstein SE, Mantz CA, Collins SP, Hamstra DA, Consortium PS
    2015 Aug;116(2):179-84. doi: 10.1016/j.radonc.2015.07.016. Epub 2015 Aug 11.
  • DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis Cancer cell
    Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE
    2015 Jul 13;28(1):97-113. doi: 10.1016/j.ccell.2015.06.004.
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      PMID:26175416 | PMC:PMC4531387 | DOI:10.1016/j.ccell.2015.06.004

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  • Endothelial CXCR7 regulates breast cancer metastasis Oncogene
    Stacer AC, Fenner J, Cavnar SP, Xiao A, Zhao S, Chang SL, Salomonnson A, Luker KE, Luker GD
    2016 Mar 31;35(13):1716-24. doi: 10.1038/onc.2015.236. Epub 2015 Jun 29.
  • High-throughput transcriptomic analysis nominates proteasomal genes as age-specific biomarkers and therapeutic targets in prostate cancer Prostate cancer and prostatic diseases
    Zhao SG, Jackson WC, Kothari V, Schipper MJ, Erho N, Evans JR, Speers C, Hamstra DA, Niknafs YS, Nguyen PL, Schaeffer EM, Ross AE, Den RB, Klein EA, Jenkins RB, Davicioni E, Feng FY
    2015 Sep;18(3):229-36. doi: 10.1038/pcan.2015.22. Epub 2015 May 19.
  • Development and validation of a novel platform-independent metastasis signature in human breast cancer PloS one
    Zhao SG, Shilkrut M, Speers C, Liu M, Wilder-Romans K, Lawrence TS, Pierce LJ, Feng FY
    2015 May 14;10(5):e0126631. doi: 10.1371/journal.pone.0126631. eCollection 2015.
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      PMID:25974184 | PMC:PMC4431866 | DOI:10.1371/journal.pone.0126631

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  • Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes European urology
    Tomlins SA, Alshalalfa M, Davicioni E, Erho N, Yousefi K, Zhao S, Haddad Z, Den RB, Dicker AP, Trock BJ, DeMarzo AM, Ross AE, Schaeffer EM, Klein EA, Magi-Galluzzi C, Karnes RJ, Jenkins RB, Feng FY
    2015 Oct;68(4):555-67. doi: 10.1016/j.eururo.2015.04.033. Epub 2015 May 8.
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      PMID:25964175 | PMC:PMC4562381 | DOI:10.1016/j.eururo.2015.04.033

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  • Development and Validation of a Novel Radiosensitivity Signature in Human Breast Cancer Clinical cancer research : an official journal of the American Association for Cancer Research
    Speers C, Zhao S, Liu M, Bartelink H, Pierce LJ, Feng FY
    2015 Aug 15;21(16):3667-77. doi: 10.1158/1078-0432.CCR-14-2898. Epub 2015 Apr 22.
  • The landscape of long noncoding RNAs in the human transcriptome Nature genetics
    Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette TR, Prensner JR, Evans JR, Zhao S, Poliakov A, Cao X, Dhanasekaran SM, Wu Y, Robinson DR, Beer DG, Feng FY, Iyer HK, Chinnaiyan AM
    2015 Mar;47(3):199-208. doi: 10.1038/ng.3192. Epub 2015 Jan 19.
  • RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1 The Lancet. Oncology
    Prensner JR, Zhao S, Erho N, Schipper M, Iyer MK, Dhanasekaran SM, Magi-Galluzzi C, Mehra R, Sahu A, Siddiqui J, Davicioni E, Den RB, Dicker AP, Karnes RJ, Wei JT, Klein EA, Jenkins RB, Chinnaiyan AM, Feng FY
    2014 Dec;15(13):1469-1480. doi: 10.1016/S1470-2045(14)71113-1. Epub 2014 Nov 17.
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      PMID:25456366 | PMC:PMC4559342 | DOI:10.1016/S1470-2045(14)71113-1

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  • Etanercept plus topical corticosteroids as initial therapy for grade one acute graft-versus-host disease after allogeneic hematopoietic cell transplantation Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    Gatza E, Braun T, Levine JE, Ferrara LM, Zhao S, Wang T, Chang L, Harris A, Pawarode A, Kitko C, Magenau JM, Yanik GA, Couriel DR, Goldstein S, Connelly J, Reddy P, Paczesny S, Choi SW
    2014 Sep;20(9):1426-34. doi: 10.1016/j.bbmt.2014.05.023. Epub 2014 Jun 2.
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      PMID:24892263 | PMC:PMC4145722 | DOI:10.1016/j.bbmt.2014.05.023

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  • Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    Chang L, Frame D, Braun T, Gatza E, Hanauer DA, Zhao S, Magenau JM, Schultz K, Tokala H, Ferrara LM, Levine JE, Reddy P, Paczesny S, Choi SW
    2014 Sep;20(9):1407-17. doi: 10.1016/j.bbmt.2014.05.022. Epub 2014 Jun 2.
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      PMID:24892262 | PMC:PMC4142041 | DOI:10.1016/j.bbmt.2014.05.022

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  • A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer<sup>1,2</sup> Translational oncology
    Zhao S, Chang SL, Linderman JJ, Feng FY, Luker GD
    2014 May 13;7(3):429-38. doi: 10.1016/j.tranon.2014.04.001. Online ahead of print.
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      PMID:24836649 | PMC:PMC4145355 | DOI:10.1016/j.tranon.2014.04.001

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  • Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes Diabetologia
    Sims-Robinson C, Zhao S, Hur J, Feldman EL
    2012 Aug;55(8):2276-84. doi: 10.1007/s00125-012-2573-6. Epub 2012 May 14.
  • Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Pediatric Nephrology Consortium (MWPNC) study The Journal of pediatrics
    Kerlin BA, Blatt NB, Fuh B, Zhao S, Lehman A, Blanchong C, Mahan JD, Smoyer WE
    2009 Jul;155(1):105-10, 110.e1. doi: 10.1016/j.jpeds.2009.01.070. Epub 2009 Apr 24.
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      PMID:19394032 | PMC:PMC3685482 | DOI:10.1016/j.jpeds.2009.01.070

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  • Significance of hemolysis on extracorporeal life support after cardiac surgery in children Pediatric nephrology (Berlin, Germany)
    Gbadegesin R, Zhao S, Charpie J, Brophy PD, Smoyer WE, Lin J
    2009 Mar;24(3):589-95. doi: 10.1007/s00467-008-1047-z. Epub 2008 Nov 12.

Contact Information

Shuang (George) Zhao, MD